Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 66522..67058 Replicon plasmid p4PS1
Accession NZ_CP013761
Organism Piscirickettsia salmonis strain AY6492A

Toxin (Protein)


Gene name yoeB Uniprot ID A0A6I5YBD1
Locus tag AVI48_RS16915 Protein ID WP_016211910.1
Coordinates 66786..67058 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0B8U9U2
Locus tag AVI48_RS16910 Protein ID WP_032126795.1
Coordinates 66522..66782 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AVI48_RS16880 61958..63111 + 1154 WP_155047011.1 IS3 family transposase -
AVI48_RS16885 63120..63827 - 708 WP_075273780.1 IS6 family transposase -
AVI48_RS16890 63966..64937 - 972 WP_033923677.1 IS91 family transposase -
AVI48_RS18070 64862..65101 - 240 WP_075275277.1 transposase zinc-binding domain-containing protein -
AVI48_RS16900 65371..65799 - 429 WP_075273782.1 site-specific integrase -
AVI48_RS16910 66522..66782 + 261 WP_032126795.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AVI48_RS16915 66786..67058 + 273 WP_016211910.1 Txe/YoeB family addiction module toxin Toxin
AVI48_RS16920 67384..68505 - 1122 WP_016211913.1 hypothetical protein -
AVI48_RS16925 68938..69336 + 399 WP_075273786.1 helix-turn-helix domain-containing protein -
AVI48_RS16940 70558..71160 + 603 Protein_93 IS30 family transposase -
AVI48_RS16945 71497..71871 + 375 WP_016212499.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..158156 158156
- flank IS/Tn - - 63120..63827 707


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-74)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10739.22 Da        Isoelectric Point: 7.8926

>T59311 WP_016211910.1 NZ_CP013761:66786-67058 [Piscirickettsia salmonis]
MSKLNLLTWSDDAWDDYLYWQDTDKKVLKKINKLIKECQRTPTEGIGHPEPLKHDFSGYWSRKIKGEHRLVYSFDATSLM
IAACRYHYDQ

Download         Length: 273 bp

>T59311 NZ_CP013761:66786-67058 [Piscirickettsia salmonis]
TTGTCAAAACTAAACTTACTTACTTGGAGTGATGATGCTTGGGATGATTACCTTTATTGGCAAGATACAGATAAAAAGGT
ACTTAAAAAAATCAATAAACTTATAAAGGAATGTCAACGCACGCCGACAGAAGGTATTGGTCATCCCGAACCTTTAAAAC
ATGATTTCAGTGGCTATTGGAGCCGAAAAATAAAGGGTGAGCATAGATTAGTTTATTCATTTGATGCGACCAGTTTAATG
ATTGCTGCATGCCGTTACCATTATGATCAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9555.93 Da        Isoelectric Point: 5.1167

>AT59311 WP_032126795.1 NZ_CP013761:66522-66782 [Piscirickettsia salmonis]
MLRDNINATAARDNFKSTCDTVCENNAPVLVKRKGAEDVVIISASDFGGMEETIHLLSSRIMATRLMRSMKQLDEGKGVQ
RDIIEE

Download         Length: 261 bp

>AT59311 NZ_CP013761:66522-66782 [Piscirickettsia salmonis]
ATGTTACGAGACAACATTAATGCTACGGCAGCGCGGGATAATTTTAAGAGTACCTGTGATACGGTGTGTGAAAACAATGC
CCCTGTACTTGTGAAGCGCAAGGGTGCTGAGGATGTCGTTATTATTTCTGCTTCTGACTTTGGTGGTATGGAAGAAACGA
TCCACTTATTAAGTAGTAGAATAATGGCAACACGCCTTATGAGAAGCATGAAACAACTTGATGAAGGTAAAGGTGTTCAA
CGTGATATTATTGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I5YBD1

Antitoxin

Source ID Structure
AlphaFold DB A0A0B8U9U2

References