Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 3900273..3900937 Replicon chromosome
Accession NZ_CP013737
Organism Herbaspirillum rubrisubalbicans M1

Toxin (Protein)


Gene name higB Uniprot ID A0A0U3LID1
Locus tag HRUBRI_RS16920 Protein ID WP_058896304.1
Coordinates 3900593..3900937 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0U3K789
Locus tag HRUBRI_RS16915 Protein ID WP_044531392.1
Coordinates 3900273..3900596 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRUBRI_RS25175 3895518..3896153 + 636 WP_058896300.1 hypothetical protein -
HRUBRI_RS16890 3896150..3896890 + 741 WP_058896301.1 hypothetical protein -
HRUBRI_RS16895 3897249..3897446 - 198 WP_058896302.1 hypothetical protein -
HRUBRI_RS16900 3897446..3897676 - 231 WP_017452985.1 hypothetical protein -
HRUBRI_RS16905 3897828..3899219 - 1392 WP_017452986.1 ABC transporter substrate-binding protein -
HRUBRI_RS16910 3899360..3900079 - 720 WP_058896303.1 FadR family transcriptional regulator -
HRUBRI_RS16915 3900273..3900596 - 324 WP_044531392.1 XRE family transcriptional regulator Antitoxin
HRUBRI_RS16920 3900593..3900937 - 345 WP_058896304.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HRUBRI_RS16925 3901042..3901947 + 906 WP_058896305.1 LysR family transcriptional regulator -
HRUBRI_RS16930 3902086..3902919 + 834 WP_058896306.1 putative hydro-lyase -
HRUBRI_RS16935 3903031..3904275 + 1245 WP_044531396.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3894707..3909104 14397


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-103)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13595.67 Da        Isoelectric Point: 9.8225

>T59244 WP_058896304.1 NZ_CP013737:c3900937-3900593 [Herbaspirillum rubrisubalbicans M1]
MEAVFKETRMFEAYRANYLSDEAYAELQQMLMRHPHAGKLIKDTGGLRKIRFPDARRCKGKRGGLRVIYYFWSEERQFWL
FSIYDKNEMADLTAEQRKLLKHVLEDELARGKTS

Download         Length: 345 bp

>T59244 NZ_CP013737:c3900937-3900593 [Herbaspirillum rubrisubalbicans M1]
ATGGAAGCCGTATTCAAAGAAACGCGAATGTTTGAAGCCTACCGGGCGAACTATCTCTCGGATGAGGCATATGCTGAACT
TCAACAGATGTTGATGAGGCATCCTCATGCGGGCAAGCTGATCAAGGATACGGGTGGGCTAAGGAAGATTCGTTTTCCTG
ATGCACGCCGTTGCAAGGGTAAACGCGGGGGCTTGCGGGTCATCTATTATTTTTGGAGTGAAGAACGTCAGTTCTGGCTT
TTTTCAATCTATGACAAAAATGAAATGGCTGACCTGACAGCCGAACAGCGCAAGCTGCTCAAACACGTTCTTGAAGATGA
ATTGGCCCGAGGGAAAACATCATGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12032.07 Da        Isoelectric Point: 11.2202

>AT59244 WP_044531392.1 NZ_CP013737:c3900596-3900273 [Herbaspirillum rubrisubalbicans M1]
MKKKRNLFDELMAGVEDMAAERKGKLTLRTTKVKLSPEPVSITAEEIQRVRSKVRVSQAIMARSLRVNARTYQNWEQGVS
RPNAQAAVLLKLVDQDPSLIARISSLV

Download         Length: 324 bp

>AT59244 NZ_CP013737:c3900596-3900273 [Herbaspirillum rubrisubalbicans M1]
ATGAAGAAGAAAAGAAACCTGTTCGACGAACTGATGGCCGGAGTCGAGGACATGGCCGCCGAGCGCAAAGGTAAGCTCAC
TTTACGCACTACCAAGGTGAAGCTATCGCCGGAACCTGTCTCGATTACTGCCGAAGAGATTCAGCGAGTCAGGAGCAAGG
TACGTGTTTCGCAAGCCATCATGGCGCGCAGTCTGCGCGTCAATGCCCGCACCTATCAGAACTGGGAACAGGGCGTCTCC
CGTCCGAATGCCCAGGCTGCCGTCTTGCTGAAGTTGGTTGATCAGGATCCTAGCCTCATCGCCCGCATCAGTTCTCTGGT
CTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U3LID1

Antitoxin

Source ID Structure
AlphaFold DB A0A0U3K789

References