Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2314556..2315165 Replicon chromosome
Accession NZ_CP013737
Organism Herbaspirillum rubrisubalbicans M1

Toxin (Protein)


Gene name higB Uniprot ID A0A0U3JRB8
Locus tag HRUBRI_RS10195 Protein ID WP_058895267.1
Coordinates 2314878..2315165 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0U3KYM0
Locus tag HRUBRI_RS10190 Protein ID WP_058895266.1
Coordinates 2314556..2314867 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRUBRI_RS10175 2310429..2311628 + 1200 WP_058895263.1 HDOD domain-containing protein -
HRUBRI_RS10180 2311634..2313727 + 2094 WP_058895264.1 EAL domain-containing protein -
HRUBRI_RS10185 2313975..2314508 + 534 WP_058895265.1 superoxide dismutase family protein -
HRUBRI_RS10190 2314556..2314867 - 312 WP_058895266.1 HigA family addiction module antidote protein Antitoxin
HRUBRI_RS10195 2314878..2315165 - 288 WP_058895267.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HRUBRI_RS10205 2315702..2316955 - 1254 WP_026051960.1 aspartate kinase -
HRUBRI_RS10210 2317483..2317761 - 279 WP_058895268.1 DUF4148 domain-containing protein -
HRUBRI_RS10215 2318012..2318923 + 912 WP_058895269.1 LysR family transcriptional regulator -
HRUBRI_RS10220 2318944..2319372 - 429 WP_017451028.1 thioredoxin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(21-95)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10710.19 Da        Isoelectric Point: 6.7084

>T59242 WP_058895267.1 NZ_CP013737:c2315165-2314878 [Herbaspirillum rubrisubalbicans M1]
MIISFRCAETEALFHGETVARFANIRAAAERKLQMLEAAATLDFLRSPPGNRLEPLQGDRSGQYSIRINSQFRLCFIWNS
IGEVGASHVEIVDYH

Download         Length: 288 bp

>T59242 NZ_CP013737:c2315165-2314878 [Herbaspirillum rubrisubalbicans M1]
ATGATCATCAGTTTCCGATGCGCAGAAACCGAAGCCCTCTTCCATGGTGAAACCGTGGCCCGGTTCGCCAACATCCGGGC
CGCGGCAGAACGCAAACTGCAGATGCTGGAAGCCGCTGCGACGTTGGATTTCCTGCGCTCACCGCCTGGCAATCGGCTGG
AACCGCTGCAGGGTGATCGAAGCGGGCAATACAGTATCCGCATCAACAGCCAATTCCGACTCTGCTTCATCTGGAACAGC
ATTGGAGAAGTAGGCGCAAGCCATGTTGAAATCGTCGATTACCACTGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11440.11 Da        Isoelectric Point: 9.1470

>AT59242 WP_058895266.1 NZ_CP013737:c2314867-2314556 [Herbaspirillum rubrisubalbicans M1]
MNPASNRMRPIHPGEILREEFLAPANLSANALAIALRVPATRIGEIVNERRGITPDTALRLARFFGGDAQSWLNLQMTHD
LKIAQQENGARIEQEVQPMVRSA

Download         Length: 312 bp

>AT59242 NZ_CP013737:c2314867-2314556 [Herbaspirillum rubrisubalbicans M1]
ATGAACCCTGCCAGCAATCGTATGCGCCCCATCCATCCGGGCGAAATCCTGCGGGAAGAATTCCTCGCCCCGGCCAACCT
CAGCGCCAATGCACTGGCCATCGCCTTGCGCGTACCCGCGACTCGCATCGGCGAAATCGTCAACGAACGGCGCGGCATCA
CGCCTGATACCGCATTGCGGCTGGCGCGATTTTTCGGTGGCGATGCGCAATCCTGGCTGAACCTGCAGATGACCCACGAC
CTCAAGATCGCCCAGCAGGAAAACGGCGCCCGCATCGAGCAGGAAGTACAACCCATGGTGCGATCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U3JRB8

Antitoxin

Source ID Structure
AlphaFold DB A0A0U3KYM0

References