Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 1705813..1706399 Replicon chromosome
Accession NZ_CP013711
Organism Klebsiella pneumoniae strain J1

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag AU361_RS08385 Protein ID WP_002920800.1
Coordinates 1706031..1706399 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag AU361_RS08380 Protein ID WP_058836921.1
Coordinates 1705813..1706034 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AU361_RS08360 1701970..1702896 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
AU361_RS08365 1702893..1704170 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
AU361_RS08370 1704167..1704934 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
AU361_RS08375 1704936..1705649 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
AU361_RS08380 1705813..1706034 + 222 WP_058836921.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AU361_RS08385 1706031..1706399 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
AU361_RS08390 1706672..1707988 + 1317 WP_004174008.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
AU361_RS08395 1708095..1708982 + 888 WP_058836922.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
AU361_RS08400 1708979..1709824 + 846 WP_004185988.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
AU361_RS08405 1709826..1710896 + 1071 WP_004150074.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1702893..1711633 8740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T59213 WP_002920800.1 NZ_CP013711:1706031-1706399 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T59213 NZ_CP013711:1706031-1706399 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8179.21 Da        Isoelectric Point: 4.7769

>AT59213 WP_058836921.1 NZ_CP013711:1705813-1706034 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELVDK

Download         Length: 222 bp

>AT59213 NZ_CP013711:1705813-1706034 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGTGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure

References