Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 4170034..4170620 Replicon chromosome
Accession NC_009648
Organism Klebsiella pneumoniae subsp. pneumoniae MGH 78578

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag KPN_RS20605 Protein ID WP_002920800.1
Coordinates 4170034..4170402 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag KPN_RS20610 Protein ID WP_004174006.1
Coordinates 4170399..4170620 (-) Length 74 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KPN_RS20585 (KPN_03810) 4165537..4166607 - 1071 WP_004150074.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -
KPN_RS20590 (KPN_03811) 4166609..4167454 - 846 WP_004185988.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
KPN_RS20595 (KPN_03812) 4167451..4168338 - 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
KPN_RS20600 (KPN_03813) 4168445..4169761 - 1317 WP_004174008.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
KPN_RS20605 (KPN_03814) 4170034..4170402 - 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KPN_RS20610 (KPN_03815) 4170399..4170620 - 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KPN_RS20615 (KPN_03816) 4170784..4171497 - 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
KPN_RS20620 (KPN_03817) 4171499..4172266 - 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
KPN_RS20625 (KPN_03818) 4172263..4173540 - 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
KPN_RS20630 (KPN_03819) 4173537..4174463 - 927 WP_015959103.1 high-affinity branched-chain amino acid ABC transporter permease LivH -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 4164800..4173540 8740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-86)

Antitoxin

(1-50)


Sequences


Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T22291 WP_002920800.1 NC_009648:c4170402-4170034 [Klebsiella pneumoniae subsp. pneumoniae MGH 78578]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T22291 NC_009648:c4170402-4170034 [Klebsiella pneumoniae subsp. pneumoniae MGH 78578]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT22291 WP_004174006.1 NC_009648:c4170620-4170399 [Klebsiella pneumoniae subsp. pneumoniae MGH 78578]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT22291 NC_009648:c4170620-4170399 [Klebsiella pneumoniae subsp. pneumoniae MGH 78578]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1


Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References