Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 4170034..4170620 Replicon chromosome
Accession NC_009648
Organism Klebsiella pneumoniae subsp. pneumoniae MGH 78578

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag KPN_RS20605 Protein ID WP_002920800.1
Coordinates 4170034..4170402 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag KPN_RS20610 Protein ID WP_004174006.1
Coordinates 4170399..4170620 (-) Length 74 a.a.

Genomic Context


KPN_RS20585KPN_RS20590KPN_RS20595KPN_RS20600KPN_RS20605KPN_RS20610KPN_RS20615KPN_RS20620KPN_RS20625KPN_RS20630
Location: 4165537..4166607 (1071 bp)
Type: Others
Protein ID: WP_004150074.1
Location: 4166609..4167454 (846 bp)
Type: Others
Protein ID: WP_004185988.1
Location: 4167451..4168338 (888 bp)
Type: Others
Protein ID: WP_002920792.1
Location: 4168445..4169761 (1317 bp)
Type: Others
Protein ID: WP_004174008.1
Location: 4170034..4170402 (369 bp)
Type: Toxin
Protein ID: WP_002920800.1
Location: 4170399..4170620 (222 bp)
Type: Antitoxin
Protein ID: WP_004174006.1
Location: 4170784..4171497 (714 bp)
Type: Others
Protein ID: WP_004145133.1
Location: 4171499..4172266 (768 bp)
Type: Others
Protein ID: WP_002920803.1
Location: 4172263..4173540 (1278 bp)
Type: Others
Protein ID: WP_004174005.1
Location: 4173537..4174463 (927 bp)
Type: Others
Protein ID: WP_015959103.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KPN_RS20585 (KPN_03810)4165537..4166607-1071WP_004150074.1sn-glycerol-3-phosphate import ATP-binding protein UgpC-
KPN_RS20590 (KPN_03811)4166609..4167454-846WP_004185988.1sn-glycerol-3-phosphate ABC transporter permease UgpE-
KPN_RS20595 (KPN_03812)4167451..4168338-888WP_002920792.1sn-glycerol-3-phosphate ABC transporter permease UgpA-
KPN_RS20600 (KPN_03813)4168445..4169761-1317WP_004174008.1sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB-
KPN_RS20605 (KPN_03814)4170034..4170402-369WP_002920800.1type II toxin-antitoxin system death-on-curing family toxinToxin
KPN_RS20610 (KPN_03815)4170399..4170620-222WP_004174006.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
KPN_RS20615 (KPN_03816)4170784..4171497-714WP_004145133.1high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF-
KPN_RS20620 (KPN_03817)4171499..4172266-768WP_002920803.1high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG-
KPN_RS20625 (KPN_03818)4172263..4173540-1278WP_004174005.1branched chain amino acid ABC transporter permease LivM-
KPN_RS20630 (KPN_03819)4173537..4174463-927WP_015959103.1high-affinity branched-chain amino acid ABC transporter permease LivH-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideProphage--4164800..41735408740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-86)

Antitoxin

(1-50)


Sequences


Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T22291 WP_002920800.1 NC_009648:c4170402-4170034 [Klebsiella pneumoniae subsp. pneumoniae MGH 78578]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T22291 NC_009648:c4170402-4170034 [Klebsiella pneumoniae subsp. pneumoniae MGH 78578]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT22291 WP_004174006.1 NC_009648:c4170620-4170399 [Klebsiella pneumoniae subsp. pneumoniae MGH 78578]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT22291 NC_009648:c4170620-4170399 [Klebsiella pneumoniae subsp. pneumoniae MGH 78578]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A0H3GUD1


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A5E5YJY7

References