Detailed information of TA system TA059201

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4765538..4766127
• Replicon: chromosome
• Accession: NZ_CP013679
• Organism: Xanthomonas oryzae pv. oryzae strain PXO602

Toxin (Protein)

• Gene name: graT
• Uniprot ID: G7TIR7
• Locus tag: ATY49_RS22605
• Protein ID: WP_012443754.1
• Coordinates: 4765846..4766127 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: ATY49_RS22600
• Protein ID: WP_011260746.1
• Coordinates: 4765538..4765828 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ATY49_RS22570	4760826..4761299	-	474	Protein_4245	DUF4123 domain-containing protein	-
ATY49_RS22575	4761302..4761736	-	435	WP_011409747.1	PAAR domain-containing protein	-
ATY49_RS22580	4761852..4762097	-	246	WP_069960049.1	hypothetical protein	-
ATY49_RS22590	4762433..4762765	+	333	WP_011260743.1	hypothetical protein	-
ATY49_RS22595	4763215..4764609	-	1395	WP_027703652.1	nucleoside hydrolase	-
ATY49_RS22600	4765538..4765828	-	291	WP_011260746.1	HigA family addiction module antidote protein	Antitoxin
ATY49_RS22605	4765846..4766127	-	282	WP_012443754.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ATY49_RS22610	4766222..4768474	-	2253	WP_069960050.1	exodeoxyribonuclease V subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (2-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-68)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11066.83 Da
• Isoelectric Point: 10.5318

>T59201 WP_012443754.1 NZ_CP013679:c4766127-4765846 [Xanthomonas oryzae pv. oryzae]
VIRSFIDKDAEKIWLGERSRRLPADIQLVARRKLRMLNAAAHLDDLRIPPANRLEALKGQRRGQYSIRINDQWRICFRWM
EGDVVQVEIVDYH

Nucleotide

• Length: 282 bp

>T59201 NZ_CP013679:c4766127-4765846 [Xanthomonas oryzae pv. oryzae]
GTGATCAGGAGCTTTATCGACAAGGACGCCGAAAAGATCTGGCTGGGTGAGCGTTCCCGCCGGTTGCCTGCCGACATCCA
ATTGGTCGCGCGCCGCAAGTTGCGCATGCTCAATGCCGCCGCACATCTCGACGATCTGCGGATCCCGCCCGCCAACCGGC
TGGAAGCGTTGAAGGGCCAGCGGCGCGGCCAGTACAGCATCCGGATCAACGATCAATGGCGCATCTGCTTCCGATGGATG
GAAGGCGATGTGGTCCAGGTCGAAATCGTCGATTACCACTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10420.07 Da
• Isoelectric Point: 7.2040

>AT59201 WP_011260746.1 NZ_CP013679:c4765828-4765538 [Xanthomonas oryzae pv. oryzae]
MTVLPNIHPGDILLEEFLEPLGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALGTSERFWLGLQADYELEQA
HRALGDLPARIKRLAA

Nucleotide

• Length: 291 bp

>AT59201 NZ_CP013679:c4765828-4765538 [Xanthomonas oryzae pv. oryzae]
ATGACGGTCCTACCCAATATCCATCCTGGCGACATTCTGCTTGAGGAGTTTCTCGAGCCTCTGGGCATCAGCCAGAATGC
ACTGGCACGCGCCACCGGCGTCCCGCCGCGCCGTATCAACGAAATCGTGCTGGGCAAGCGCGGCATCACTGCCGACACTG
CCGTGCGTCTGGCCGCCGCGTTGGGCACCTCCGAGCGCTTCTGGCTGGGCCTGCAGGCCGACTACGAGCTGGAACAGGCG
CATCGCGCGCTGGGCGATTTGCCGGCACGGATCAAGCGGCTGGCGGCGTGA

Structures

Toxin

• AlphaFold DB: A0A0K0GFW5