Detailed information of TA system TA059189

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4774871..4775460
• Replicon: chromosome
• Accession: NZ_CP013676
• Organism: Xanthomonas oryzae pv. oryzae strain PXO282

Toxin (Protein)

• Gene name: graT
• Uniprot ID: G7TIR7
• Locus tag: ATY46_RS22845
• Protein ID: WP_012443754.1
• Coordinates: 4775179..4775460 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: ATY46_RS22840
• Protein ID: WP_011260746.1
• Coordinates: 4774871..4775161 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ATY46_RS22810 (ATY46_22045)	4770016..4770633	-	618	WP_082325600.1	DUF4123 domain-containing protein	-
ATY46_RS22815 (ATY46_22050)	4770636..4771058	-	423	WP_042465811.1	PAAR domain-containing protein	-
ATY46_RS22820 (ATY46_22055)	4771186..4771512	-	327	WP_228329596.1	hypothetical protein	-
ATY46_RS22830 (ATY46_22065)	4771767..4772099	+	333	WP_011260743.1	hypothetical protein	-
ATY46_RS28295	4772259..4772446	+	188	Protein_4309	hypothetical protein	-
ATY46_RS22835 (ATY46_22070)	4772549..4773943	-	1395	WP_027703652.1	type III secretion system effector XopQ	-
ATY46_RS22840 (ATY46_22075)	4774871..4775161	-	291	WP_011260746.1	HigA family addiction module antitoxin	Antitoxin
ATY46_RS22845 (ATY46_22080)	4775179..4775460	-	282	WP_012443754.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ATY46_RS22850 (ATY46_22085)	4775555..4777807	-	2253	WP_069960050.1	exodeoxyribonuclease V subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (2-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-68)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11066.83 Da
• Isoelectric Point: 10.5318

>T59189 WP_012443754.1 NZ_CP013676:c4775460-4775179 [Xanthomonas oryzae pv. oryzae]
VIRSFIDKDAEKIWLGERSRRLPADIQLVARRKLRMLNAAAHLDDLRIPPANRLEALKGQRRGQYSIRINDQWRICFRWM
EGDVVQVEIVDYH

Nucleotide

• Length: 282 bp

>T59189 NZ_CP013676:c4775460-4775179 [Xanthomonas oryzae pv. oryzae]
GTGATCAGGAGCTTTATCGACAAGGACGCCGAAAAGATCTGGCTGGGTGAGCGTTCCCGCCGGTTGCCTGCCGACATCCA
ATTGGTCGCGCGCCGCAAGTTGCGCATGCTCAATGCCGCCGCACATCTCGACGATCTGCGGATCCCGCCCGCCAACCGGC
TGGAAGCGTTGAAGGGCCAGCGGCGCGGCCAGTACAGCATCCGGATCAACGATCAATGGCGCATCTGCTTCCGATGGATG
GAAGGCGATGTGGTCCAGGTCGAAATCGTCGATTACCACTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10420.07 Da
• Isoelectric Point: 7.2040

>AT59189 WP_011260746.1 NZ_CP013676:c4775161-4774871 [Xanthomonas oryzae pv. oryzae]
MTVLPNIHPGDILLEEFLEPLGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALGTSERFWLGLQADYELEQA
HRALGDLPARIKRLAA

Nucleotide

• Length: 291 bp

>AT59189 NZ_CP013676:c4775161-4774871 [Xanthomonas oryzae pv. oryzae]
ATGACGGTCCTACCCAATATCCATCCTGGCGACATTCTGCTTGAGGAGTTTCTCGAGCCTCTGGGCATCAGCCAGAATGC
ACTGGCACGCGCCACCGGCGTCCCGCCGCGCCGTATCAACGAAATCGTGCTGGGCAAGCGCGGCATCACTGCCGACACTG
CCGTGCGTCTGGCCGCCGCGTTGGGCACCTCCGAGCGCTTCTGGCTGGGCCTGCAGGCCGACTACGAGCTGGAACAGGCG
CATCGCGCGCTGGGCGATTTGCCGGCACGGATCAAGCGGCTGGCGGCGTGA

Structures

Toxin

• AlphaFold DB: A0A0K0GFW5