Detailed information of TA system TA059174

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4720957..4721546
• Replicon: chromosome
• Accession: NZ_CP013670
• Organism: Xanthomonas oryzae pv. oryzae strain PXO71

Toxin (Protein)

• Gene name: graT
• Uniprot ID: G7TIR7
• Locus tag: ATY42_RS22465
• Protein ID: WP_012443754.1
• Coordinates: 4721265..4721546 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: ATY42_RS22460
• Protein ID: WP_011260746.1
• Coordinates: 4720957..4721247 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ATY42_RS22430	4716245..4716718	-	474	Protein_4216	DUF4123 domain-containing protein	-
ATY42_RS22435	4716721..4717155	-	435	WP_011409747.1	PAAR domain-containing protein	-
ATY42_RS22440	4717271..4717516	-	246	WP_069960049.1	hypothetical protein	-
ATY42_RS22450	4717852..4718184	+	333	WP_011260743.1	hypothetical protein	-
ATY42_RS22455	4718634..4720028	-	1395	WP_027703652.1	nucleoside hydrolase	-
ATY42_RS22460	4720957..4721247	-	291	WP_011260746.1	HigA family addiction module antidote protein	Antitoxin
ATY42_RS22465	4721265..4721546	-	282	WP_012443754.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ATY42_RS22470	4721641..4723893	-	2253	WP_069960050.1	exodeoxyribonuclease V subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (2-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-68)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11066.83 Da
• Isoelectric Point: 10.5318

>T59174 WP_012443754.1 NZ_CP013670:c4721546-4721265 [Xanthomonas oryzae pv. oryzae]
VIRSFIDKDAEKIWLGERSRRLPADIQLVARRKLRMLNAAAHLDDLRIPPANRLEALKGQRRGQYSIRINDQWRICFRWM
EGDVVQVEIVDYH

Nucleotide

• Length: 282 bp

>T59174 NZ_CP013670:c4721546-4721265 [Xanthomonas oryzae pv. oryzae]
GTGATCAGGAGCTTTATCGACAAGGACGCCGAAAAGATCTGGCTGGGTGAGCGTTCCCGCCGGTTGCCTGCCGACATCCA
ATTGGTCGCGCGCCGCAAGTTGCGCATGCTCAATGCCGCCGCACATCTCGACGATCTGCGGATCCCGCCCGCCAACCGGC
TGGAAGCGTTGAAGGGCCAGCGGCGCGGCCAGTACAGCATCCGGATCAACGATCAATGGCGCATCTGCTTCCGATGGATG
GAAGGCGATGTGGTCCAGGTCGAAATCGTCGATTACCACTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10420.07 Da
• Isoelectric Point: 7.2040

>AT59174 WP_011260746.1 NZ_CP013670:c4721247-4720957 [Xanthomonas oryzae pv. oryzae]
MTVLPNIHPGDILLEEFLEPLGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALGTSERFWLGLQADYELEQA
HRALGDLPARIKRLAA

Nucleotide

• Length: 291 bp

>AT59174 NZ_CP013670:c4721247-4720957 [Xanthomonas oryzae pv. oryzae]
ATGACGGTCCTACCCAATATCCATCCTGGCGACATTCTGCTTGAGGAGTTTCTCGAGCCTCTGGGCATCAGCCAGAATGC
ACTGGCACGCGCCACCGGCGTCCCGCCGCGCCGTATCAACGAAATCGTGCTGGGCAAGCGCGGCATCACTGCCGACACTG
CCGTGCGTCTGGCCGCCGCGTTGGGCACCTCCGAGCGCTTCTGGCTGGGCCTGCAGGCCGACTACGAGCTGGAACAGGCG
CATCGCGCGCTGGGCGATTTGCCGGCACGGATCAAGCGGCTGGCGGCGTGA

Structures

Toxin

• AlphaFold DB: A0A0K0GFW5