Detailed information of TA system TA059066

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 1003660..1004172
• Replicon: chromosome
• Accession: NZ_CP013651
• Organism: Streptococcus sp. A12

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: ATM98_RS04920
• Protein ID: WP_061564280.1
• Coordinates: 1003660..1003914 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: ATM98_RS04925
• Protein ID: WP_185759930.1
• Coordinates: 1003918..1004172 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ATM98_RS04900	999568..1000449	-	882	WP_061564278.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
ATM98_RS04905	1000482..1001309	-	828	WP_048691689.1	amino acid ABC transporter substrate-binding protein	-
ATM98_RS04910	1001438..1002580	-	1143	WP_061564279.1	amidohydrolase	-
ATM98_RS04915	1002769..1003485	-	717	WP_006146163.1	YebC/PmpR family DNA-binding transcriptional regulator	-
ATM98_RS04920	1003660..1003914	-	255	WP_061564280.1	Txe/YoeB family addiction module toxin	Toxin
ATM98_RS04925	1003918..1004172	-	255	WP_185759930.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
ATM98_RS04930	1004551..1005645	-	1095	WP_061564282.1	nucleotidyltransferase	-
ATM98_RS04935	1005652..1006392	-	741	WP_061564808.1	class I SAM-dependent methyltransferase	-
ATM98_RS04940	1006563..1006916	-	354	WP_061564283.1	ribosome silencing factor	-
ATM98_RS04945	1006931..1007431	-	501	WP_048691706.1	cysteine hydrolase	-
ATM98_RS04950	1007432..1008028	-	597	WP_048691709.1	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK	-
ATM98_RS04955	1008025..1008657	-	633	WP_048691710.1	nicotinate-nucleotide adenylyltransferase	-
ATM98_RS04960	1008679..1008990	-	312	WP_006595720.1	ribosome assembly RNA-binding protein YhbY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-75)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10124.63 Da
• Isoelectric Point: 7.9789

>T59066 WP_061564280.1 NZ_CP013651:c1003914-1003660 [Streptococcus sp. A12]
MLLKFTEEAWKDYCYWQSQDKKILKRINSLIKEIQRDPFTGIGKPEPLKYDFQGAWSRRIDAENRLIYMLDESGVAFLSF
KDHY

Nucleotide

• Length: 255 bp

>T59066 NZ_CP013651:c1003914-1003660 [Streptococcus sp. A12]
ATGTTACTCAAGTTTACAGAAGAGGCCTGGAAGGATTATTGTTACTGGCAAAGTCAGGACAAAAAAATACTGAAGCGGAT
TAATAGCCTTATTAAAGAGATCCAAAGGGATCCATTTACTGGGATTGGTAAGCCTGAGCCCTTGAAATATGACTTTCAAG
GAGCATGGTCAAGACGGATTGATGCAGAGAATCGCCTGATTTATATGCTAGATGAGTCAGGTGTCGCTTTTCTCTCTTTT
AAAGACCATTACTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9731.99 Da
• Isoelectric Point: 4.6768

>AT59066 WP_185759930.1 NZ_CP013651:c1004172-1003918 [Streptococcus sp. A12]
MEAVVYSTFRNHLKDYMRKVNDEFEPLTVVNKNPDEDIVVISKSEWDSLQETLRLAQNKELSDKVLRGMAEVRAGQVQLH
EIEG

Nucleotide

• Length: 255 bp

>AT59066 NZ_CP013651:c1004172-1003918 [Streptococcus sp. A12]
ATGGAAGCAGTCGTTTATTCAACATTCCGCAATCATTTGAAGGATTATATGAGGAAGGTGAACGATGAGTTTGAGCCTTT
GACAGTCGTGAATAAGAATCCAGACGAAGATATTGTGGTCATCTCTAAGAGCGAGTGGGACAGCCTACAAGAAACCCTGA
GACTAGCTCAGAACAAGGAATTGTCAGATAAGGTCTTGCGGGGTATGGCAGAAGTCCGAGCTGGTCAGGTTCAACTCCAT
GAGATTGAGGGGTAA