Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 2649231..2649829 Replicon chromosome
Accession NZ_CP013650
Organism Lacimicrobium alkaliphilum strain YelD216

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AT746_RS11995 Protein ID WP_062480620.1
Coordinates 2649506..2649829 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0U2JJ61
Locus tag AT746_RS11990 Protein ID WP_062480618.1
Coordinates 2649231..2649509 (-) Length 93 a.a.

Genomic Context

AT746_RS11980AT746_RS11985AT746_RS11990AT746_RS11995AT746_RS12000AT746_RS12010AT746_RS12015
Location: 2646106..2647824 (1719 bp)
Type: Others
Protein ID: WP_062480616.1
Location: 2648169..2649166 (998 bp)
Type: Others
Protein ID: Protein_2350
Location: 2649231..2649509 (279 bp)
Type: Antitoxin
Protein ID: WP_062480618.1
Location: 2649506..2649829 (324 bp)
Type: Toxin
Protein ID: WP_062480620.1
Location: 2650145..2650666 (522 bp)
Type: Others
Protein ID: WP_062480622.1
Location: 2651797..2652390 (594 bp)
Type: Others
Protein ID: WP_062480624.1
Location: 2652682..2653746 (1065 bp)
Type: Others
Protein ID: WP_062480626.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AT746_RS119802646106..2647824+1719WP_062480616.1hypothetical protein-
AT746_RS119852648169..2649166+998Protein_2350SEC-C domain-containing protein-
AT746_RS119902649231..2649509-279WP_062480618.1helix-turn-helix domain-containing proteinAntitoxin
AT746_RS119952649506..2649829-324WP_062480620.1type II toxin-antitoxin system RelE/ParE family toxinToxin
AT746_RS120002650145..2650666-522WP_062480622.1PEP-CTERM sorting domain-containing protein-
AT746_RS120102651797..2652390-594WP_062480624.1dCTP deaminase-
AT746_RS120152652682..2653746-1065WP_062480626.1iron-sulfur cluster carrier protein ApbC-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(15-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-85)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12416.68 Da        Isoelectric Point: 10.5532

>T59065 WP_062480620.1 NZ_CP013650:c2649829-2649506 [Lacimicrobium alkaliphilum]
MTWKVDFYDGVEDIILRMPPKIQARMIKLLELMEKHGANLGPPHTESMGHGLFEIRAKAKEGIGRSLFCYLTGKRIYVLH
AFVKKSRKTPKHELELARQRQKEVNKS

Download         Length: 324 bp

>T59065 NZ_CP013650:c2649829-2649506 [Lacimicrobium alkaliphilum]
ATGACTTGGAAAGTCGATTTTTACGATGGCGTTGAAGATATCATTTTGCGAATGCCACCAAAGATCCAGGCAAGAATGAT
TAAATTACTGGAACTGATGGAAAAGCACGGGGCAAATTTAGGCCCACCTCATACTGAATCGATGGGGCATGGTCTGTTCG
AAATAAGAGCAAAAGCTAAGGAAGGGATTGGTCGCAGCCTGTTTTGCTACTTAACAGGCAAACGCATTTATGTATTACAT
GCTTTCGTGAAAAAATCACGGAAAACCCCTAAACATGAACTTGAGCTGGCCCGTCAACGCCAGAAAGAGGTAAACAAATC
ATGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10498.02 Da        Isoelectric Point: 8.0034

>AT59065 WP_062480618.1 NZ_CP013650:c2649509-2649231 [Lacimicrobium alkaliphilum]
MSLQNLKQRALDNPEVKAEYDDLESEFNLIDKLLTMRTTAGLTQEQVAERMKTQKSNISRLERGNANPSWATLLKYAHAC
GFDLSLKMQKIP

Download         Length: 279 bp

>AT59065 NZ_CP013650:c2649509-2649231 [Lacimicrobium alkaliphilum]
ATGAGCTTACAAAATCTGAAACAGCGTGCACTCGATAATCCCGAGGTTAAGGCTGAATATGACGACCTGGAGTCTGAATT
TAATTTAATTGATAAGTTGCTCACGATGCGCACCACTGCAGGGCTGACGCAAGAGCAGGTGGCTGAGCGAATGAAAACGC
AAAAGAGCAATATCAGTCGTCTGGAGCGTGGCAATGCCAACCCCAGTTGGGCGACCCTGCTCAAATATGCCCATGCTTGT
GGTTTTGATTTGTCACTGAAAATGCAAAAAATACCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0U2JJ61

References