Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2529278..2529888 Replicon chromosome
Accession NZ_CP013650
Organism Lacimicrobium alkaliphilum strain YelD216

Toxin (Protein)


Gene name graT Uniprot ID A0A0U2Z7D3
Locus tag AT746_RS11525 Protein ID WP_062480443.1
Coordinates 2529607..2529888 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID A0A0U3ALJ3
Locus tag AT746_RS11520 Protein ID WP_062480442.1
Coordinates 2529278..2529592 (-) Length 105 a.a.

Genomic Context

AT746_RS11490AT746_RS11500AT746_RS11505AT746_RS11510AT746_RS11515AT746_RS11540AT746_RS11545AT746_RS11495AT746_RS11520AT746_RS11525AT746_RS11530AT746_RS11550
Location: 2524868..2525389 (522 bp)
Type: Others
Protein ID: WP_062480432.1
Location: 2526610..2527503 (894 bp)
Type: Others
Protein ID: WP_062480436.1
Location: 2527786..2528286 (501 bp)
Type: Others
Protein ID: WP_062480438.1
Location: 2528279..2528491 (213 bp)
Type: Others
Protein ID: WP_062480440.1
Location: 2528708..2529130 (423 bp)
Type: Others
Protein ID: WP_082633246.1
Location: 2531054..2531284 (231 bp)
Type: Others
Protein ID: WP_062480454.1
Location: 2531281..2531616 (336 bp)
Type: Others
Protein ID: WP_062480455.1
Location: 2525599..2526480 (882 bp)
Type: Others
Protein ID: WP_062480434.1
Location: 2529278..2529592 (315 bp)
Type: Antitoxin
Protein ID: WP_062480442.1
Location: 2529607..2529888 (282 bp)
Type: Toxin
Protein ID: WP_062480443.1
Location: 2530022..2530387 (366 bp)
Type: Others
Protein ID: WP_062480449.1
Location: 2531884..2534343 (2460 bp)
Type: Others
Protein ID: WP_062480457.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AT746_RS114902524868..2525389+522WP_062480432.1DUF2062 domain-containing protein-
AT746_RS114952525599..2526480-882WP_062480434.1NmrA family NAD(P)-binding protein-
AT746_RS115002526610..2527503+894WP_062480436.1LysR family transcriptional regulator-
AT746_RS115052527786..2528286+501WP_062480438.1hypothetical protein-
AT746_RS115102528279..2528491+213WP_062480440.1helix-turn-helix transcriptional regulator-
AT746_RS115152528708..2529130+423WP_082633246.1nucleotidyl transferase AbiEii/AbiGii toxin family protein-
AT746_RS115202529278..2529592-315WP_062480442.1HigA family addiction module antidote proteinAntitoxin
AT746_RS115252529607..2529888-282WP_062480443.1type II toxin-antitoxin system RelE/ParE family toxinToxin
AT746_RS115302530022..2530387-366WP_062480449.1hypothetical protein-
AT746_RS115402531054..2531284+231WP_062480454.1AbrB/MazE/SpoVT family DNA-binding domain-containing protein-
AT746_RS115452531281..2531616+336WP_062480455.1endoribonuclease MazF-
AT746_RS115502531884..2534343-2460WP_062480457.1SIR2 family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(10-102)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10721.15 Da        Isoelectric Point: 7.8770

>T59062 WP_062480443.1 NZ_CP013650:c2529888-2529607 [Lacimicrobium alkaliphilum]
MIKSFADKRTQELYSKGKSKKFPADVAPRAARKLEYVDLAVQLEDLKVPPGNRLHPLTGNRQGQHAISINDQWRICFRFE
DGDAYEVEVCDYH

Download         Length: 282 bp

>T59062 NZ_CP013650:c2529888-2529607 [Lacimicrobium alkaliphilum]
ATGATCAAATCCTTCGCTGACAAACGAACCCAAGAACTGTACTCCAAAGGTAAGTCAAAGAAATTTCCTGCGGATGTTGC
ACCGAGAGCCGCCAGAAAACTCGAGTACGTGGATCTGGCTGTGCAGCTGGAGGATTTAAAGGTGCCGCCCGGCAATCGCC
TTCACCCGCTGACGGGAAACAGGCAGGGGCAGCACGCAATATCAATAAATGATCAGTGGCGTATCTGTTTTCGTTTTGAA
GATGGTGATGCGTACGAGGTCGAAGTGTGTGACTACCACTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11606.37 Da        Isoelectric Point: 9.9896

>AT59062 WP_062480442.1 NZ_CP013650:c2529592-2529278 [Lacimicrobium alkaliphilum]
MAILNTAGMQRKPTHPGEMLREDFLVDYGLTVAGLAKSLGVSRQSVNELLRERRAVSPEMALRLARLFGNSPEFWLNAQR
SVDLWTAAQSVKDEVERIKPLNAA

Download         Length: 315 bp

>AT59062 NZ_CP013650:c2529592-2529278 [Lacimicrobium alkaliphilum]
ATGGCTATTCTTAACACTGCCGGCATGCAGCGCAAACCGACTCATCCTGGTGAAATGCTCAGAGAAGATTTCCTGGTGGA
CTATGGCCTGACCGTTGCCGGGTTGGCTAAATCTCTGGGCGTCTCACGCCAGTCAGTTAACGAATTACTGCGCGAACGTC
GTGCTGTCAGTCCTGAAATGGCGCTCCGGCTTGCCCGTTTGTTTGGTAATTCGCCGGAATTCTGGCTGAACGCGCAGCGA
TCTGTCGATCTGTGGACTGCCGCTCAGTCAGTCAAGGATGAAGTGGAGCGGATCAAGCCACTGAATGCTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0U2Z7D3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0U3ALJ3

References