Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1444557..1445161 Replicon chromosome
Accession NZ_CP013650
Organism Lacimicrobium alkaliphilum strain YelD216

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AT746_RS06570 Protein ID WP_062478073.1
Coordinates 1444557..1444874 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0U2RL04
Locus tag AT746_RS06575 Protein ID WP_062478076.1
Coordinates 1444871..1445161 (+) Length 97 a.a.

Genomic Context

AT746_RS06565AT746_RS06570AT746_RS06575AT746_RS06580AT746_RS06555AT746_RS06560
Location: 1443389..1444303 (915 bp)
Type: Others
Protein ID: WP_062478070.1
Location: 1444557..1444874 (318 bp)
Type: Toxin
Protein ID: WP_062478073.1
Location: 1444871..1445161 (291 bp)
Type: Antitoxin
Protein ID: WP_062478076.1
Location: 1445446..1446114 (669 bp)
Type: Others
Protein ID: WP_062478080.1
Location: 1440058..1441572 (1515 bp)
Type: Others
Protein ID: WP_156413761.1
Location: 1441671..1443242 (1572 bp)
Type: Others
Protein ID: WP_062478067.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AT746_RS065551440058..1441572-1515WP_156413761.1SpoVR family protein-
AT746_RS065601441671..1443242-1572WP_062478067.1response regulator-
AT746_RS065651443389..1444303+915WP_062478070.1pirin family protein-
AT746_RS065701444557..1444874+318WP_062478073.1type II toxin-antitoxin system RelE/ParE family toxinToxin
AT746_RS065751444871..1445161+291WP_062478076.1helix-turn-helix domain-containing proteinAntitoxin
AT746_RS065801445446..1446114+669WP_062478080.1DUF1707 and DUF2154 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(42-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-85)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12235.19 Da        Isoelectric Point: 9.3562

>T59061 WP_062478073.1 NZ_CP013650:1444557-1444874 [Lacimicrobium alkaliphilum]
MVIIETPVFTRLITELMSDDEYKDLQEALVNRPDMGALIRNSGGLRKIRWALEGRGKSGGVRIIYYWMTADDQLYMLLAY
PKNEKENLTDAQTKVLRQIVQRWSK

Download         Length: 318 bp

>T59061 NZ_CP013650:1444557-1444874 [Lacimicrobium alkaliphilum]
ATGGTAATCATAGAAACCCCCGTTTTCACAAGGCTTATCACCGAGTTAATGAGTGATGACGAATACAAGGACTTGCAGGA
AGCGCTGGTCAACCGTCCGGATATGGGAGCCTTGATCAGAAACAGTGGCGGTCTGCGAAAGATACGCTGGGCCTTGGAAG
GCCGGGGAAAAAGTGGCGGTGTACGGATCATTTACTACTGGATGACAGCCGATGATCAGCTATATATGCTGCTGGCGTAC
CCCAAGAATGAGAAAGAAAATTTAACTGATGCGCAAACCAAGGTGCTCAGACAGATAGTCCAAAGGTGGTCGAAATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10753.25 Da        Isoelectric Point: 7.3218

>AT59061 WP_062478076.1 NZ_CP013650:1444871-1445161 [Lacimicrobium alkaliphilum]
MNEEQFNALLESVRQADEIIQGKAKAARVLEFAEPEVKSIRAKTGLTQERFANVLGVSKRTLENWEQGRRHPTGPARALL
KILDADPIHALEALNH

Download         Length: 291 bp

>AT59061 NZ_CP013650:1444871-1445161 [Lacimicrobium alkaliphilum]
ATGAATGAAGAACAGTTTAACGCCTTGCTGGAAAGTGTCCGACAGGCGGATGAAATTATCCAGGGAAAGGCTAAAGCTGC
CCGGGTGCTCGAGTTTGCTGAACCAGAAGTAAAGTCCATCCGCGCCAAGACCGGGCTGACTCAGGAGCGCTTCGCCAATG
TATTAGGGGTGAGCAAACGCACTCTGGAAAACTGGGAGCAGGGACGGCGCCATCCGACCGGGCCTGCCCGCGCGCTGCTT
AAAATACTGGACGCTGATCCCATACATGCACTGGAAGCTCTGAATCATTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0U2RL04

References