Detailed information of TA system TA059042

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1633488..1634067
• Replicon: chromosome
• Accession: NZ_CP013621
• Organism: Staphylococcus aureus strain RIVM3897

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: AUC50_RS07925
• Protein ID: WP_001025401.1
• Coordinates: 1633822..1634067 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1633488..1633853 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AUC50_RS07885	1630231..1630788	-	558	WP_000645045.1	DUF2815 family protein	-
AUC50_RS07890	1630814..1631980	-	1167	WP_000762545.1	DUF2800 domain-containing protein	-
AUC50_RS07895	1631977..1632339	-	363	WP_000985976.1	hypothetical protein	-
AUC50_RS07900	1632354..1632677	-	324	WP_000174994.1	hypothetical protein	-
AUC50_RS07905	1632756..1632917	-	162	WP_001285948.1	DUF1270 domain-containing protein	-
AUC50_RS07910	1632930..1633193	-	264	WP_001124198.1	helix-turn-helix domain-containing protein	-
AUC50_RS07915	1633218..1633433	-	216	WP_001097552.1	hypothetical protein	-
AUC50_RS07920	1633488..1633853	+	366	WP_016170627.1	hypothetical protein	Antitoxin
AUC50_RS07925	1633822..1634067	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
AUC50_RS07930	1634096..1634872	-	777	WP_031796638.1	Rha family transcriptional regulator	-
AUC50_RS07935	1634895..1635122	-	228	WP_015978369.1	helix-turn-helix transcriptional regulator	-
AUC50_RS07940	1635276..1635905	+	630	WP_029549401.1	XRE family transcriptional regulator	-
AUC50_RS07945	1635962..1636558	+	597	WP_031796639.1	hypothetical protein	-
AUC50_RS07950	1636788..1636934	+	147	WP_001795334.1	hypothetical protein	-
AUC50_RS07955	1636931..1637545	-	615	WP_000191466.1	hypothetical protein	-
AUC50_RS07960	1637671..1638876	+	1206	WP_031585161.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1593631..1651632	58001

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T59042 WP_001025401.1 NZ_CP013621:c1634067-1633822 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T59042 NZ_CP013621:c1634067-1633822 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT59042 NZ_CP013621:1633488-1633853 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTACGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin