Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2460295..2460479 Replicon chromosome
Accession NZ_CP013619
Organism Staphylococcus aureus strain RIVM1607

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag AUC49_RS12255 Protein ID WP_000482647.1
Coordinates 2460372..2460479 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2460295..2460355 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AUC49_RS12230 2455749..2455916 - 168 WP_001798790.1 hypothetical protein -
AUC49_RS12240 2456147..2457880 - 1734 WP_000486511.1 ABC transporter ATP-binding protein/permease -
AUC49_RS12245 2457905..2459668 - 1764 WP_001064818.1 ABC transporter ATP-binding protein/permease -
- 2460295..2460355 + 61 - - Antitoxin
AUC49_RS12255 2460372..2460479 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
AUC49_RS12260 2460613..2460999 - 387 WP_000779355.1 flippase GtxA -
AUC49_RS12265 2461266..2462408 + 1143 WP_001176859.1 glycerate kinase -
AUC49_RS12270 2462468..2463127 + 660 WP_000831300.1 hypothetical protein -
AUC49_RS12275 2463315..2464526 + 1212 WP_001191974.1 multidrug effflux MFS transporter -
AUC49_RS12280 2464649..2465122 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T59036 WP_000482647.1 NZ_CP013619:c2460479-2460372 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T59036 NZ_CP013619:c2460479-2460372 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT59036 NZ_CP013619:2460295-2460355 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References