Detailed information of TA system TA059035

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprG3-SprA2AS/-
• Location: 2164438..2164636
• Replicon: chromosome
• Accession: NZ_CP013619
• Organism: Staphylococcus aureus strain RIVM1607

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: AUC49_RS10695
• Protein ID: WP_001802298.1
• Coordinates: 2164532..2164636 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2164438..2164476 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AUC49_RS10675	2160558..2161223	-	666	WP_001024099.1	SDR family oxidoreductase	-
AUC49_RS10680	2161375..2161695	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
AUC49_RS10685	2161697..2162677	+	981	WP_000019735.1	CDF family zinc efflux transporter CzrB	-
AUC49_RS10690	2162943..2164034	+	1092	WP_000495673.1	hypothetical protein	-
-	2164438..2164476	+	39	-	-	Antitoxin
AUC49_RS10695	2164532..2164636	-	105	WP_001802298.1	hypothetical protein	Toxin
AUC49_RS14295	2165316..2165474	+	159	WP_001792784.1	hypothetical protein	-
AUC49_RS14300	2165910..2166002	+	93	WP_000220902.1	hypothetical protein	-
AUC49_RS10700	2166132..2166989	-	858	WP_000370942.1	Cof-type HAD-IIB family hydrolase	-
AUC49_RS10705	2167057..2167839	-	783	WP_000908191.1	ABC transporter ATP-binding protein	-
AUC49_RS10710	2168129..2168737	-	609	WP_000101714.1	TIR domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-137)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T59035 WP_001802298.1 NZ_CP013619:c2164636-2164532 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T59035 NZ_CP013619:c2164636-2164532 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Nucleotide

• Length: 39 bp

>AT59035 NZ_CP013619:2164438-2164476 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin