Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2468557..2468741 Replicon chromosome
Accession NZ_CP013616
Organism Staphylococcus aureus strain RIVM1295

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag AUC48_RS12410 Protein ID WP_000482647.1
Coordinates 2468634..2468741 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2468557..2468617 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AUC48_RS12385 2464011..2464178 - 168 WP_001798790.1 hypothetical protein -
AUC48_RS12395 2464409..2466142 - 1734 WP_000486511.1 ABC transporter ATP-binding protein/permease -
AUC48_RS12400 2466167..2467930 - 1764 WP_001064818.1 ABC transporter ATP-binding protein/permease -
- 2468557..2468617 + 61 - - Antitoxin
AUC48_RS12410 2468634..2468741 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
AUC48_RS12415 2468875..2469261 - 387 WP_000779355.1 flippase GtxA -
AUC48_RS12420 2469528..2470670 + 1143 WP_001176859.1 glycerate kinase -
AUC48_RS12425 2470730..2471389 + 660 WP_000831300.1 hypothetical protein -
AUC48_RS12430 2471577..2472788 + 1212 WP_001191974.1 multidrug effflux MFS transporter -
AUC48_RS12435 2472911..2473384 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-110)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T59027 WP_000482647.1 NZ_CP013616:c2468741-2468634 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T59027 NZ_CP013616:c2468741-2468634 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT59027 NZ_CP013616:2468557-2468617 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References