58777

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2958296..2958944 Replicon chromosome
Accession NZ_CP013475
Organism Mycobacterium tuberculosis strain 1458

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag BTB1458_RS13975 Protein ID WP_003899414.1
Coordinates 2958296..2958619 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag BTB1458_RS13980 Protein ID WP_003899415.1
Coordinates 2958699..2958944 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTB1458_RS13945 2953619..2954617 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
BTB1458_RS13950 2954631..2955095 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
BTB1458_RS13955 2955083..2955334 + 252 WP_003908028.1 hypothetical protein -
BTB1458_RS13960 2955505..2956944 - 1440 WP_003901443.1 phage major capsid protein -
BTB1458_RS13965 2956952..2957485 - 534 WP_003899412.1 HK97 family phage prohead protease -
BTB1458_RS21515 2957638..2958129 - 492 WP_003900541.1 phage terminase small subunit P27 family -
BTB1458_RS13975 2958296..2958619 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
BTB1458_RS13980 2958699..2958944 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
BTB1458_RS13985 2958941..2960368 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
BTB1458_RS13990 2960370..2960762 - 393 WP_003899417.1 DUF2742 domain-containing protein -
BTB1458_RS13995 2960759..2961019 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
BTB1458_RS14000 2961036..2961398 - 363 WP_003900543.1 hypothetical protein -
BTB1458_RS14005 2961401..2962528 - 1128 WP_003899420.1 site-specific integrase -
BTB1458_RS14010 2962673..2962900 - 228 WP_003899421.1 hypothetical protein -
BTB1458_RS21520 2962897..2963286 - 390 WP_003899422.1 hypothetical protein -
BTB1458_RS14015 2963192..2963464 + 273 WP_003900544.1 hypothetical protein -
BTB1458_RS14020 2963563..2963796 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2953619..2962528 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(15-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T58777 WP_003899414.1 NZ_CP013475:c2958619-2958296 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T58777 NZ_CP013475:c2958619-2958296 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT58777 WP_003899415.1 NZ_CP013475:c2958944-2958699 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT58777 NZ_CP013475:c2958944-2958699 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References