58761

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Gp49-HTH_37
Location 2182945..2183813 Replicon chromosome
Accession NZ_CP013475
Organism Mycobacterium tuberculosis strain 1458

Toxin (Protein)


Gene name higB Uniprot ID P9WJA4
Locus tag BTB1458_RS10190 Protein ID WP_010886136.1
Coordinates 2182945..2183322 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G0TLM0
Locus tag BTB1458_RS10195 Protein ID WP_003409886.1
Coordinates 2183364..2183813 (+) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTB1458_RS10140 2178734..2179186 - 453 WP_003899095.1 lipoprotein -
BTB1458_RS10145 2179250..2179651 + 402 WP_003409869.1 hypothetical protein -
BTB1458_RS10150 2179644..2179826 - 183 WP_003409870.1 hypothetical protein -
BTB1458_RS10155 2179940..2180290 - 351 WP_003409871.1 hypothetical protein -
BTB1458_RS10160 2180301..2181203 - 903 WP_003899097.1 hypothetical protein -
BTB1458_RS10165 2181224..2181415 - 192 WP_003409876.1 hypothetical protein -
BTB1458_RS10170 2181416..2181712 - 297 WP_003409877.1 hypothetical protein -
BTB1458_RS10175 2181952..2182167 + 216 WP_003409878.1 antitoxin -
BTB1458_RS10180 2182164..2182475 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
BTB1458_RS22380 2182449..2182970 - 522 WP_003904745.1 hypothetical protein -
BTB1458_RS10190 2182945..2183322 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB Toxin
BTB1458_RS10195 2183364..2183813 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
BTB1458_RS10200 2183810..2184355 + 546 WP_003409891.1 SecB-like chaperone -
BTB1458_RS10205 2184244..2184858 - 615 WP_003901296.1 hypothetical protein -
BTB1458_RS10210 2184907..2185203 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin -
BTB1458_RS10215 2185200..2185451 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin -
BTB1458_RS10220 2185438..2185932 + 495 WP_003899099.1 hypothetical protein -
BTB1458_RS10225 2186092..2186499 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
BTB1458_RS10230 2186503..2186775 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
BTB1458_RS10235 2186808..2188028 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(27-113)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-91)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14397.77 Da        Isoelectric Point: 10.8862

>T58761 WP_010886136.1 NZ_CP013475:2182945-2183322 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI

Download         Length: 378 bp

>T58761 NZ_CP013475:2182945-2183322 [Mycobacterium tuberculosis]
GTGCCGCCCCCTGATCCAGCCGCCATGGGTACCTGGAAGTTCTTCCGGGCATCTGTGGATGGCCGGCCGGTATTCAAGAA
GGAGTTCGACAAGCTTCCTGATCAGGCCCGGGCCGCGCTGATCGTGCTAATGCAGCGGTATCTCGTCGGCGACCTCGCCG
CAGGGAGCATCAAACCGATTCGTGGCGACATTCTGGAGTTGCGATGGCATGAGGCGAACAACCACTTCCGGGTACTGTTC
TTCCGCTGGGGCCAGCATCCCGTAGCGCTGACAGCGTTCTACAAGAACCAGCAGAAGACTCCCAAGACGAAGATCGAGAC
GGCCCTGGACCGGCAGAAAATCTGGAAAAGAGCCTTCGGCGACACCCCACCGATCTGA

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16760.16 Da        Isoelectric Point: 8.0771

>AT58761 WP_003409886.1 NZ_CP013475:2183364-2183813 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA

Download         Length: 450 bp

>AT58761 NZ_CP013475:2183364-2183813 [Mycobacterium tuberculosis]
ATGAGCATTGACTTCCCTTTGGGTGACGACCTCGCCGGCTATATTGCCGAGGCGATTGCGGCTGATCCCAGCTTCAAAGG
CACTCTCGAAGACGCCGAGGAGGCACGCAGGCTGGTCGATGCGCTGATTGCGCTGCGCAAGCACTGCCAGCTGAGCCAGG
TTGAGGTTGCTAAGCGTATGGGGGTGCGCCAGCCCACCGTGAGCGGTTTCGAGAAGGAACCCAGCGACCCCAAACTGTCT
ACGCTGCAACGTTATGCCCGTGCATTGGACGCCCGGCTGCGGCTGGTGCTCGAAGTTCCCACGCTTCGCGAAGTGCCTAC
GTGGCATCGGCTCTCCTCTTATCGGGGCTCCGCACGGGACCATCAGGTCCGGGTGGGTGCAGACAAGGAAATCCTGATGC
AGACGAACTGGGCCCGCCACATTTCGGTTCGGCAGGTTGAGGTGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AWK
PDB 7NBU

Antitoxin

Source ID Structure
AlphaFold DB G0TLM0

References