Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1592098..1592798 Replicon chromosome
Accession NZ_CP013464
Organism Burkholderia ubonensis strain MSMB1471WGS

Toxin (Protein)


Gene name mqsR Uniprot ID A0A118WVK7
Locus tag WM29_RS23310 Protein ID WP_059970093.1
Coordinates 1592502..1592798 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID A0A119AGU5
Locus tag WM29_RS23305 Protein ID WP_010096397.1
Coordinates 1592098..1592499 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WM29_RS23285 1587774..1589123 - 1350 WP_059970085.1 LLM class flavin-dependent oxidoreductase -
WM29_RS23290 1589144..1590187 - 1044 WP_059970087.1 LLM class flavin-dependent oxidoreductase -
WM29_RS23295 1590236..1591177 - 942 WP_059970089.1 ABC transporter substrate-binding protein -
WM29_RS23300 1591229..1591783 - 555 WP_059970091.1 GNAT family N-acetyltransferase -
WM29_RS23305 1592098..1592499 - 402 WP_010096397.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
WM29_RS23310 1592502..1592798 - 297 WP_059970093.1 type II toxin-antitoxin system MqsR family toxin Toxin
WM29_RS23315 1592907..1593941 - 1035 WP_059970202.1 succinylglutamate desuccinylase/aspartoacylase family protein -
WM29_RS23320 1594254..1594526 - 273 WP_059588792.1 hypothetical protein -
WM29_RS23325 1594745..1596292 - 1548 WP_069237838.1 sensor domain-containing diguanylate cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Antitoxin MqsA/HigA-2

(1-131)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11081.91 Da        Isoelectric Point: 9.5736

>T58716 WP_059970093.1 NZ_CP013464:c1592798-1592502 [Burkholderia ubonensis]
MEKNTPHCKLSRVKALVETGKVRLTATAVIGARQLGFTELEAIGVVMSLTAVDFHKSMTTYADHTIWQDVYRRRTVRGDV
YLKLTVIDDVLIVSFKEQ

Download         Length: 297 bp

>T58716 NZ_CP013464:c1592798-1592502 [Burkholderia ubonensis]
ATGGAAAAGAATACGCCTCACTGCAAGCTGTCCCGAGTCAAAGCGCTCGTCGAGACCGGCAAGGTGCGTTTGACCGCAAC
AGCGGTAATCGGCGCCCGACAACTGGGCTTCACCGAACTGGAAGCAATCGGCGTCGTGATGTCGCTGACGGCCGTCGATT
TCCACAAGAGCATGACGACCTATGCCGACCACACGATATGGCAAGACGTGTATCGGCGCCGCACCGTGCGTGGCGACGTG
TATCTGAAACTGACAGTGATCGACGACGTGCTGATCGTGTCTTTCAAGGAGCAATGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14505.86 Da        Isoelectric Point: 8.4900

>AT58716 WP_010096397.1 NZ_CP013464:c1592499-1592098 [Burkholderia ubonensis]
MKCPACGAAKLIRDTRDIPYTYKGRSTVVPGITGDFCPACGESVLDIDEATRLGEAVTEFNKQVNATIVDPKFIAKVRKK
LMLDQREAAELFGGGINAFSRYETGKTNPPLALVKLLKILDRHPDLLAEVRAA

Download         Length: 402 bp

>AT58716 NZ_CP013464:c1592499-1592098 [Burkholderia ubonensis]
ATGAAGTGTCCTGCGTGCGGCGCCGCAAAACTGATCCGTGACACACGAGACATTCCCTATACGTACAAGGGTCGATCGAC
GGTCGTCCCCGGCATTACGGGCGATTTCTGTCCGGCCTGCGGAGAGTCGGTGCTGGACATCGACGAGGCGACCCGTCTCG
GCGAAGCGGTAACGGAGTTCAACAAGCAGGTGAACGCGACCATCGTCGACCCGAAGTTCATCGCGAAGGTGCGCAAGAAG
CTGATGCTGGATCAGCGCGAAGCGGCCGAGCTCTTTGGCGGCGGCATCAACGCGTTTTCCCGCTATGAGACCGGCAAGAC
GAACCCGCCGCTCGCGCTGGTGAAGTTGTTGAAGATCCTGGACCGTCATCCGGATCTGCTTGCCGAAGTACGCGCGGCGT
AG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A118WVK7

Antitoxin

Source ID Structure
AlphaFold DB A0A119AGU5

References