Detailed information of TA system TA058693

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1710713..1711413
• Replicon: chromosome
• Accession: NZ_CP013447
• Organism: Burkholderia ubonensis strain MSMB1189WGS isolate MSMB1189WGS

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: WK67_RS27535
• Protein ID: WP_059880227.1
• Coordinates: 1710713..1711009 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: A0A119AGU5
• Locus tag: WK67_RS27540
• Protein ID: WP_010096397.1
• Coordinates: 1711012..1711413 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WK67_RS27520	1707168..1708715	+	1548	WP_060153677.1	sensor domain-containing diguanylate cyclase	-
WK67_RS27525	1708954..1709226	+	273	WP_059714113.1	hypothetical protein	-
WK67_RS27530	1709570..1710604	+	1035	WP_045565468.1	succinylglutamate desuccinylase/aspartoacylase family protein	-
WK67_RS27535	1710713..1711009	+	297	WP_059880227.1	type II toxin-antitoxin system MqsR family toxin	Toxin
WK67_RS27540	1711012..1711413	+	402	WP_010096397.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
WK67_RS27545	1711678..1712232	+	555	WP_045564956.1	GNAT family N-acetyltransferase	-
WK67_RS27550	1712288..1713229	+	942	WP_060133746.1	ABC transporter substrate-binding protein	-
WK67_RS27555	1713275..1714354	+	1080	WP_060153679.1	LLM class flavin-dependent oxidoreductase	-
WK67_RS27560	1714351..1715700	+	1350	WP_059725115.1	LLM class flavin-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-97)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11067.90 Da
• Isoelectric Point: 9.5736

>T58693 WP_059880227.1 NZ_CP013447:1710713-1711009 [Burkholderia ubonensis]
MEKNTPHCKLSRVKALVETGKVRLTASAVIGARQLGLTEMDAIGVVMSLTTVDFHKSMTTYADHTIWQDVYRRRTVRGDV
YLKLTVIDDVLIVSFKEQ

Nucleotide

• Length: 297 bp

>T58693 NZ_CP013447:1710713-1711009 [Burkholderia ubonensis]
ATGGAAAAGAATACGCCTCACTGCAAGCTGTCCCGAGTCAAAGCGCTCGTCGAGACCGGCAAGGTGCGTTTGACCGCGAG
TGCGGTAATCGGCGCTCGGCAACTTGGCTTAACCGAAATGGACGCGATCGGTGTCGTGATGTCGCTGACAACCGTCGATT
TCCACAAGAGCATGACGACCTATGCCGACCACACAATATGGCAAGACGTGTATCGGCGCCGCACCGTGCGTGGCGACGTG
TATCTGAAACTGACAGTGATCGACGACGTGCTGATCGTGTCTTTCAAGGAGCAATGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14505.86 Da
• Isoelectric Point: 8.4900

>AT58693 WP_010096397.1 NZ_CP013447:1711012-1711413 [Burkholderia ubonensis]
MKCPACGAAKLIRDTRDIPYTYKGRSTVVPGITGDFCPACGESVLDIDEATRLGEAVTEFNKQVNATIVDPKFIAKVRKK
LMLDQREAAELFGGGINAFSRYETGKTNPPLALVKLLKILDRHPDLLAEVRAA

Nucleotide

• Length: 402 bp

>AT58693 NZ_CP013447:1711012-1711413 [Burkholderia ubonensis]
ATGAAGTGTCCTGCGTGCGGTGCCGCAAAACTGATCCGCGACACACGAGACATTCCCTATACCTACAAGGGTCGATCAAC
GGTCGTCCCCGGCATAACGGGCGATTTTTGTCCGGCCTGCGGAGAGTCGGTGCTGGACATCGACGAGGCGACCCGTCTCG
GCGAAGCGGTAACGGAGTTCAACAAGCAGGTGAACGCGACCATCGTCGACCCGAAGTTCATCGCGAAGGTGCGCAAGAAG
CTGATGCTGGATCAGCGTGAGGCGGCGGAACTCTTCGGCGGCGGGATCAACGCGTTCTCCCGCTACGAGACCGGCAAGAC
GAACCCGCCGCTCGCGCTGGTGAAGTTGTTGAAGATCCTGGACCGTCATCCGGACCTGCTTGCCGAAGTACGCGCGGCGT
AG

Structures

Antitoxin

• AlphaFold DB: A0A119AGU5