Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Tad-HTH_37 |
| Location | 227783..228440 | Replicon | chromosome |
| Accession | NZ_CP013447 | ||
| Organism | Burkholderia ubonensis strain MSMB1189WGS isolate MSMB1189WGS | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A1B4PXC5 |
| Locus tag | WK67_RS21410 | Protein ID | WP_069270810.1 |
| Coordinates | 228108..228440 (-) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | A0A0D0H342 |
| Locus tag | WK67_RS35885 | Protein ID | WP_010100491.1 |
| Coordinates | 227783..228115 (-) | Length | 111 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| WK67_RS21390 | 222858..224333 | + | 1476 | WP_069270808.1 | PLP-dependent aminotransferase family protein | - |
| WK67_RS21395 | 224404..224826 | - | 423 | WP_059716974.1 | NUDIX domain-containing protein | - |
| WK67_RS21400 | 225053..225352 | + | 300 | WP_060153491.1 | helix-turn-helix domain-containing protein | - |
| WK67_RS21405 | 225363..226715 | + | 1353 | WP_069270809.1 | aspartate aminotransferase family protein | - |
| WK67_RS37415 | 227041..227595 | + | 555 | WP_155123160.1 | hypothetical protein | - |
| WK67_RS35885 | 227783..228115 | - | 333 | WP_010100491.1 | helix-turn-helix domain-containing protein | Antitoxin |
| WK67_RS21410 | 228108..228440 | - | 333 | WP_069270810.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| WK67_RS38115 | 228437..228622 | - | 186 | WP_196222178.1 | hypothetical protein | - |
| WK67_RS21415 | 228716..229336 | + | 621 | WP_059479339.1 | LysE family translocator | - |
| WK67_RS21420 | 229407..229880 | + | 474 | WP_069270811.1 | cupin domain-containing protein | - |
| WK67_RS21425 | 229894..230637 | + | 744 | WP_080485706.1 | SDR family oxidoreductase | - |
| WK67_RS21430 | 230680..230979 | - | 300 | WP_059625567.1 | AzlD family protein | - |
| WK67_RS21435 | 230972..231709 | - | 738 | WP_069270813.1 | AzlC family ABC transporter permease | - |
| WK67_RS21440 | 231835..232293 | + | 459 | WP_006486309.1 | Lrp/AsnC family transcriptional regulator | - |
| WK67_RS21445 | 232397..232966 | + | 570 | WP_069270814.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 12845.97 Da Isoelectric Point: 10.4938
>T58690 WP_069270810.1 NZ_CP013447:c228440-228108 [Burkholderia ubonensis]
MKIHWTIVYYYERVKRDVFAFPAGILANYLRLLDLMQEFGADLRMPHSRAMGNGLFELRPNGREGIGRVFYCTHVGRQVV
VLHSFVKKTQETPPQELRIAQARLREVRNG
MKIHWTIVYYYERVKRDVFAFPAGILANYLRLLDLMQEFGADLRMPHSRAMGNGLFELRPNGREGIGRVFYCTHVGRQVV
VLHSFVKKTQETPPQELRIAQARLREVRNG
Download Length: 333 bp
>T58690 NZ_CP013447:c228440-228108 [Burkholderia ubonensis]
ATGAAAATTCATTGGACGATCGTCTACTACTACGAACGCGTGAAGCGTGACGTTTTCGCGTTCCCCGCCGGGATTCTTGC
GAACTACCTTCGGCTGCTGGACCTGATGCAGGAATTCGGCGCAGATCTACGAATGCCTCACTCCCGCGCAATGGGTAACG
GGTTGTTCGAGTTGCGTCCAAACGGTAGGGAAGGTATCGGGCGAGTGTTCTATTGCACGCATGTGGGGCGGCAAGTCGTT
GTGCTGCACTCCTTCGTCAAGAAGACACAGGAGACGCCGCCGCAAGAATTGCGGATCGCCCAAGCACGTTTGAGAGAGGT
GCGGAATGGCTAA
ATGAAAATTCATTGGACGATCGTCTACTACTACGAACGCGTGAAGCGTGACGTTTTCGCGTTCCCCGCCGGGATTCTTGC
GAACTACCTTCGGCTGCTGGACCTGATGCAGGAATTCGGCGCAGATCTACGAATGCCTCACTCCCGCGCAATGGGTAACG
GGTTGTTCGAGTTGCGTCCAAACGGTAGGGAAGGTATCGGGCGAGTGTTCTATTGCACGCATGTGGGGCGGCAAGTCGTT
GTGCTGCACTCCTTCGTCAAGAAGACACAGGAGACGCCGCCGCAAGAATTGCGGATCGCCCAAGCACGTTTGAGAGAGGT
GCGGAATGGCTAA
Antitoxin
Download Length: 111 a.a. Molecular weight: 11724.35 Da Isoelectric Point: 9.5722
>AT58690 WP_010100491.1 NZ_CP013447:c228115-227783 [Burkholderia ubonensis]
MAKVATKRVRAEGFDPVPHTADDTARLLADGKVKAAYDALEDEYTALRALLAARQEAGLTQAQVAERMGTTASAVSRLEA
SLTSEKHSPSFATLRKYAAACGKRLVISFA
MAKVATKRVRAEGFDPVPHTADDTARLLADGKVKAAYDALEDEYTALRALLAARQEAGLTQAQVAERMGTTASAVSRLEA
SLTSEKHSPSFATLRKYAAACGKRLVISFA
Download Length: 333 bp
>AT58690 NZ_CP013447:c228115-227783 [Burkholderia ubonensis]
ATGGCTAAGGTAGCAACGAAGCGTGTTCGCGCTGAGGGATTCGATCCGGTTCCGCATACGGCGGACGATACGGCTCGTCT
GCTCGCAGATGGCAAGGTCAAGGCGGCCTATGATGCGCTGGAAGATGAATACACCGCGCTGCGCGCACTATTGGCCGCGC
GGCAAGAGGCTGGACTGACTCAAGCACAGGTCGCTGAGCGCATGGGTACGACGGCGTCAGCCGTGTCGCGCCTCGAAGCA
TCGCTCACTAGCGAAAAGCATTCGCCCTCGTTTGCGACATTGCGAAAATATGCGGCCGCATGTGGCAAGAGGCTCGTGAT
TTCGTTTGCTTAG
ATGGCTAAGGTAGCAACGAAGCGTGTTCGCGCTGAGGGATTCGATCCGGTTCCGCATACGGCGGACGATACGGCTCGTCT
GCTCGCAGATGGCAAGGTCAAGGCGGCCTATGATGCGCTGGAAGATGAATACACCGCGCTGCGCGCACTATTGGCCGCGC
GGCAAGAGGCTGGACTGACTCAAGCACAGGTCGCTGAGCGCATGGGTACGACGGCGTCAGCCGTGTCGCGCCTCGAAGCA
TCGCTCACTAGCGAAAAGCATTCGCCCTCGTTTGCGACATTGCGAAAATATGCGGCCGCATGTGGCAAGAGGCTCGTGAT
TTCGTTTGCTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1B4PXC5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0D0H342 |