Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 227783..228440 Replicon chromosome
Accession NZ_CP013447
Organism Burkholderia ubonensis strain MSMB1189WGS isolate MSMB1189WGS

Toxin (Protein)


Gene name higB Uniprot ID A0A1B4PXC5
Locus tag WK67_RS21410 Protein ID WP_069270810.1
Coordinates 228108..228440 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0D0H342
Locus tag WK67_RS35885 Protein ID WP_010100491.1
Coordinates 227783..228115 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WK67_RS21390 222858..224333 + 1476 WP_069270808.1 PLP-dependent aminotransferase family protein -
WK67_RS21395 224404..224826 - 423 WP_059716974.1 NUDIX domain-containing protein -
WK67_RS21400 225053..225352 + 300 WP_060153491.1 helix-turn-helix domain-containing protein -
WK67_RS21405 225363..226715 + 1353 WP_069270809.1 aspartate aminotransferase family protein -
WK67_RS37415 227041..227595 + 555 WP_155123160.1 hypothetical protein -
WK67_RS35885 227783..228115 - 333 WP_010100491.1 helix-turn-helix domain-containing protein Antitoxin
WK67_RS21410 228108..228440 - 333 WP_069270810.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WK67_RS38115 228437..228622 - 186 WP_196222178.1 hypothetical protein -
WK67_RS21415 228716..229336 + 621 WP_059479339.1 LysE family translocator -
WK67_RS21420 229407..229880 + 474 WP_069270811.1 cupin domain-containing protein -
WK67_RS21425 229894..230637 + 744 WP_080485706.1 SDR family oxidoreductase -
WK67_RS21430 230680..230979 - 300 WP_059625567.1 AzlD family protein -
WK67_RS21435 230972..231709 - 738 WP_069270813.1 AzlC family ABC transporter permease -
WK67_RS21440 231835..232293 + 459 WP_006486309.1 Lrp/AsnC family transcriptional regulator -
WK67_RS21445 232397..232966 + 570 WP_069270814.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(19-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(48-102)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12845.97 Da        Isoelectric Point: 10.4938

>T58690 WP_069270810.1 NZ_CP013447:c228440-228108 [Burkholderia ubonensis]
MKIHWTIVYYYERVKRDVFAFPAGILANYLRLLDLMQEFGADLRMPHSRAMGNGLFELRPNGREGIGRVFYCTHVGRQVV
VLHSFVKKTQETPPQELRIAQARLREVRNG

Download         Length: 333 bp

>T58690 NZ_CP013447:c228440-228108 [Burkholderia ubonensis]
ATGAAAATTCATTGGACGATCGTCTACTACTACGAACGCGTGAAGCGTGACGTTTTCGCGTTCCCCGCCGGGATTCTTGC
GAACTACCTTCGGCTGCTGGACCTGATGCAGGAATTCGGCGCAGATCTACGAATGCCTCACTCCCGCGCAATGGGTAACG
GGTTGTTCGAGTTGCGTCCAAACGGTAGGGAAGGTATCGGGCGAGTGTTCTATTGCACGCATGTGGGGCGGCAAGTCGTT
GTGCTGCACTCCTTCGTCAAGAAGACACAGGAGACGCCGCCGCAAGAATTGCGGATCGCCCAAGCACGTTTGAGAGAGGT
GCGGAATGGCTAA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 11724.35 Da        Isoelectric Point: 9.5722

>AT58690 WP_010100491.1 NZ_CP013447:c228115-227783 [Burkholderia ubonensis]
MAKVATKRVRAEGFDPVPHTADDTARLLADGKVKAAYDALEDEYTALRALLAARQEAGLTQAQVAERMGTTASAVSRLEA
SLTSEKHSPSFATLRKYAAACGKRLVISFA

Download         Length: 333 bp

>AT58690 NZ_CP013447:c228115-227783 [Burkholderia ubonensis]
ATGGCTAAGGTAGCAACGAAGCGTGTTCGCGCTGAGGGATTCGATCCGGTTCCGCATACGGCGGACGATACGGCTCGTCT
GCTCGCAGATGGCAAGGTCAAGGCGGCCTATGATGCGCTGGAAGATGAATACACCGCGCTGCGCGCACTATTGGCCGCGC
GGCAAGAGGCTGGACTGACTCAAGCACAGGTCGCTGAGCGCATGGGTACGACGGCGTCAGCCGTGTCGCGCCTCGAAGCA
TCGCTCACTAGCGAAAAGCATTCGCCCTCGTTTGCGACATTGCGAAAATATGCGGCCGCATGTGGCAAGAGGCTCGTGAT
TTCGTTTGCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4PXC5

Antitoxin

Source ID Structure
AlphaFold DB A0A0D0H342

References