Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 981605..982260 Replicon chromosome
Accession NZ_CP013446
Organism Burkholderia ubonensis strain MSMB1189WGS isolate MSMB1189WGS

Toxin (Protein)


Gene name higB Uniprot ID A0A1B4PPS3
Locus tag WK67_RS07890 Protein ID WP_059590707.1
Coordinates 981916..982260 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1B4PPY9
Locus tag WK67_RS07885 Protein ID WP_059590709.1
Coordinates 981605..981919 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WK67_RS07860 977062..977499 - 438 WP_010091646.1 transcription antitermination factor NusB -
WK67_RS07865 977496..978011 - 516 WP_010091647.1 6,7-dimethyl-8-ribityllumazine synthase -
WK67_RS07870 978066..979211 - 1146 WP_010091648.1 3,4-dihydroxy-2-butanone-4-phosphate synthase -
WK67_RS07875 979342..979860 - 519 WP_042584533.1 DUF1993 domain-containing protein -
WK67_RS07880 980204..981373 + 1170 WP_069269953.1 sensor domain-containing diguanylate cyclase -
WK67_RS07885 981605..981919 - 315 WP_059590709.1 XRE family transcriptional regulator Antitoxin
WK67_RS07890 981916..982260 - 345 WP_059590707.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WK67_RS07895 982574..983203 - 630 WP_059887589.1 riboflavin synthase -
WK67_RS07900 983218..984339 - 1122 WP_069269954.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
WK67_RS07905 984355..985641 - 1287 WP_059953170.1 glutamate-1-semialdehyde 2,1-aminomutase -
WK67_RS07910 985785..986237 - 453 WP_069269955.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(45-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(45-90)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13410.31 Da        Isoelectric Point: 9.5311

>T58688 WP_059590707.1 NZ_CP013446:c982260-981916 [Burkholderia ubonensis]
VHATFIELPPFSRERENYLADDEYAVLQKELLANPEAGDLIKGTGGLRKLRFADKRRQKGKRGGLRVIYYYWVSGYQFWL
FTLYDKDEMADLTSDERKAFAKLLEREVTIRSKQ

Download         Length: 345 bp

>T58688 NZ_CP013446:c982260-981916 [Burkholderia ubonensis]
GTGCATGCGACCTTCATCGAACTGCCGCCATTTTCCCGTGAACGCGAGAACTACCTCGCGGATGATGAGTACGCCGTGCT
GCAGAAAGAGCTGCTGGCTAATCCCGAGGCCGGTGACTTGATCAAGGGAACCGGCGGTCTGCGGAAGCTGAGGTTCGCTG
ACAAACGTCGCCAGAAAGGCAAACGCGGTGGCCTACGAGTGATCTATTACTACTGGGTTAGCGGTTATCAATTCTGGTTG
TTCACGCTGTACGACAAGGATGAAATGGCAGACCTGACCAGTGACGAGCGGAAAGCCTTCGCGAAGCTACTGGAAAGAGA
GGTCACGATACGGAGCAAGCAATGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11660.53 Da        Isoelectric Point: 10.3374

>AT58688 WP_059590709.1 NZ_CP013446:c981919-981605 [Burkholderia ubonensis]
MKKRNLFAELTEGLDALAAEREEKITLRKIKAEVPDALDVSPAEIKAVREASHASQAVMARSLRINVRTYQNWEQGKAKP
NAQAATLIRLVAKHPETLRMLETL

Download         Length: 315 bp

>AT58688 NZ_CP013446:c981919-981605 [Burkholderia ubonensis]
ATGAAGAAGCGAAATCTGTTTGCTGAATTGACTGAGGGTCTCGACGCCCTTGCTGCCGAGCGCGAAGAGAAAATCACACT
GCGCAAGATCAAGGCCGAGGTGCCCGATGCGCTCGACGTTTCGCCGGCCGAAATCAAGGCCGTGCGCGAAGCATCTCACG
CATCTCAAGCTGTCATGGCTCGAAGCCTGCGCATCAACGTGCGCACGTATCAGAATTGGGAACAAGGCAAGGCCAAACCC
AACGCACAGGCCGCCACGCTGATCCGACTGGTCGCCAAGCACCCGGAAACGCTTCGGATGCTGGAAACGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4PPS3

Antitoxin

Source ID Structure
AlphaFold DB A0A1B4PPY9

References