Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 447669..448271 Replicon chromosome
Accession NZ_CP013446
Organism Burkholderia ubonensis strain MSMB1189WGS isolate MSMB1189WGS

Toxin (Protein)


Gene name higB Uniprot ID A0A837UPF4
Locus tag WK67_RS05415 Protein ID WP_059592488.1
Coordinates 447954..448271 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A118IY59
Locus tag WK67_RS05410 Protein ID WP_059592487.1
Coordinates 447669..447950 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WK67_RS05380 443428..444048 + 621 WP_059626734.1 ubiquinol-cytochrome c reductase iron-sulfur subunit -
WK67_RS05385 444048..445436 + 1389 WP_059626733.1 cytochrome bc complex cytochrome b subunit -
WK67_RS05390 445458..446216 + 759 WP_042582959.1 cytochrome c1 -
WK67_RS05395 446310..446921 + 612 WP_006400565.1 glutathione S-transferase N-terminal domain-containing protein -
WK67_RS05400 446994..447503 + 510 WP_042582960.1 ClpXP protease specificity-enhancing factor -
WK67_RS05410 447669..447950 - 282 WP_059592487.1 helix-turn-helix domain-containing protein Antitoxin
WK67_RS05415 447954..448271 - 318 WP_059592488.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WK67_RS35060 448502..448807 - 306 WP_080485625.1 hypothetical protein -
WK67_RS05425 448881..449222 - 342 WP_059808466.1 helix-turn-helix domain-containing protein -
WK67_RS37005 449678..450253 - 576 WP_155123062.1 hypothetical protein -
WK67_RS05430 450535..452406 - 1872 WP_060138940.1 hypothetical protein -
WK67_RS37985 452926..453147 + 222 WP_196222159.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-82)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12026.23 Da        Isoelectric Point: 10.3463

>T58687 WP_059592488.1 NZ_CP013446:c448271-447954 [Burkholderia ubonensis]
MTWHVELIPEATAELLALPPDMRARFLHIAEMLAEFGPQRVGMPHVRPLEGKLWEIRMTGRDGIARAIYVARTGQRLVVL
HVFVKKTQKTPHRAMETACARMKED

Download         Length: 318 bp

>T58687 NZ_CP013446:c448271-447954 [Burkholderia ubonensis]
ATGACTTGGCATGTTGAGTTGATACCCGAGGCCACAGCCGAATTGCTGGCGCTGCCGCCCGATATGCGCGCCCGTTTCCT
CCACATCGCAGAGATGCTTGCGGAGTTCGGTCCGCAACGCGTCGGGATGCCCCACGTGCGCCCACTGGAGGGAAAGCTGT
GGGAAATCCGCATGACGGGGCGAGATGGCATCGCCCGGGCGATATACGTTGCACGGACGGGGCAGCGCTTGGTCGTGCTG
CACGTGTTCGTGAAAAAGACGCAGAAGACACCCCACCGAGCCATGGAAACGGCCTGTGCCCGGATGAAGGAGGATTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10180.67 Da        Isoelectric Point: 10.6655

>AT58687 WP_059592487.1 NZ_CP013446:c447950-447669 [Burkholderia ubonensis]
MTSLATLKKRLLADPATQAEYDAQAPEFAVARELVAARVRAGLTQEQVAERMQTTQSTIARMESGRTMPSLRTLSRYAEA
TGSRAVVRLEVAK

Download         Length: 282 bp

>AT58687 NZ_CP013446:c447950-447669 [Burkholderia ubonensis]
ATGACCAGCCTTGCAACCCTGAAGAAGCGCCTGCTGGCCGACCCGGCTACCCAGGCCGAGTATGACGCACAAGCGCCGGA
GTTTGCCGTTGCGCGCGAACTCGTCGCTGCGCGCGTACGTGCCGGATTGACGCAGGAACAGGTGGCCGAGAGGATGCAGA
CGACCCAATCGACCATCGCGCGCATGGAAAGCGGTCGCACGATGCCGTCGCTGCGGACGCTGTCCCGCTATGCCGAGGCG
ACGGGAAGCCGTGCCGTGGTACGCCTCGAGGTCGCGAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837UPF4

Antitoxin

Source ID Structure
AlphaFold DB A0A118IY59

References