Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1693551..1694251 Replicon chromosome
Accession NZ_CP013444
Organism Burkholderia cepacia strain MSMB1184WGS

Toxin (Protein)


Gene name mqsR Uniprot ID A0A1B4Q0E5
Locus tag WT26_RS27635 Protein ID WP_069274407.1
Coordinates 1693551..1693847 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID A0A1B4Q0G9
Locus tag WT26_RS27640 Protein ID WP_069274408.1
Coordinates 1693850..1694251 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WT26_RS27620 1690006..1691553 + 1548 WP_069274405.1 sensor domain-containing diguanylate cyclase -
WT26_RS27625 1691792..1692064 + 273 WP_069274406.1 hypothetical protein -
WT26_RS27630 1692408..1693442 + 1035 WP_069275162.1 succinylglutamate desuccinylase/aspartoacylase family protein -
WT26_RS27635 1693551..1693847 + 297 WP_069274407.1 type II toxin-antitoxin system MqsR family toxin Toxin
WT26_RS27640 1693850..1694251 + 402 WP_069274408.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
WT26_RS27645 1694519..1695073 + 555 WP_069274409.1 GNAT family N-acetyltransferase -
WT26_RS27650 1695128..1696081 + 954 WP_069274410.1 ABC transporter substrate-binding protein -
WT26_RS27655 1696127..1697206 + 1080 WP_069274411.1 LLM class flavin-dependent oxidoreductase -
WT26_RS27660 1697203..1698552 + 1350 WP_069274412.1 LLM class flavin-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(74-127)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11221.14 Da        Isoelectric Point: 10.1761

>T58682 WP_069274407.1 NZ_CP013444:1693551-1693847 [Burkholderia cepacia]
MEKRRPHCKLSRVKALVETGKVRLTASAVIGARQLGLTEMDAIGVVMSLTDLDFHKSMTTYADHTIWQDVYRRRTVRGDV
YLKLTVIDDVLIVSFKER

Download         Length: 297 bp

>T58682 NZ_CP013444:1693551-1693847 [Burkholderia cepacia]
ATGGAAAAGAGAAGGCCTCATTGCAAGCTGTCCCGAGTCAAAGCGCTCGTCGAGACCGGCAAGGTGCGTTTGACCGCGAG
TGCGGTAATCGGCGCTCGGCAACTTGGCTTAACCGAAATGGACGCGATCGGTGTCGTGATGTCGCTGACCGACCTCGACT
TTCACAAGAGCATGACGACGTACGCCGACCACACAATATGGCAAGACGTGTATCGGCGCCGCACCGTGCGTGGCGACGTG
TACCTGAAACTGACCGTGATCGACGATGTGCTGATCGTGTCTTTCAAGGAGCGATGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14446.70 Da        Isoelectric Point: 8.8343

>AT58682 WP_069274408.1 NZ_CP013444:1693850-1694251 [Burkholderia cepacia]
MKCPACGAAKLVRDTRDIPYTYKGRSTVVPGITGDFCPACGESVLDLDEATRLGEAISAFNKQVNATIVDPNYIAKVRKK
LRLDQREAAELFGGGVNAFSRYETGKTNPPLALVKLLKILDRHPDLLAEVRAA

Download         Length: 402 bp

>AT58682 NZ_CP013444:1693850-1694251 [Burkholderia cepacia]
ATGAAGTGTCCTGCATGCGGTGCCGCGAAGCTCGTCCGCGACACGCGCGACATCCCTTATACCTACAAGGGTCGATCAAC
GGTCGTCCCCGGCATAACGGGCGATTTTTGTCCGGCCTGCGGGGAATCGGTACTGGATCTCGACGAGGCGACCCGTCTCG
GCGAAGCGATCAGCGCGTTCAACAAGCAGGTGAACGCCACCATCGTCGACCCGAATTACATCGCGAAGGTGCGCAAGAAG
CTGCGGCTCGACCAGCGCGAGGCGGCCGAGCTTTTCGGCGGCGGCGTCAACGCGTTCTCCCGTTACGAAACAGGCAAGAC
GAACCCGCCGCTCGCCCTCGTGAAACTGCTGAAGATCCTCGACCGTCATCCGGACCTGCTTGCCGAAGTACGCGCGGCGT
AG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4Q0E5

Antitoxin

Source ID Structure
AlphaFold DB A0A1B4Q0G9

References