Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 227173..227830 Replicon chromosome
Accession NZ_CP013444
Organism Burkholderia cepacia strain MSMB1184WGS

Toxin (Protein)


Gene name higB Uniprot ID A0A1B4PXC5
Locus tag WT26_RS21485 Protein ID WP_069270810.1
Coordinates 227498..227830 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0D0H342
Locus tag WT26_RS36080 Protein ID WP_010100491.1
Coordinates 227173..227505 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WT26_RS21465 222253..223728 + 1476 WP_069270808.1 PLP-dependent aminotransferase family protein -
WT26_RS21470 223799..224221 - 423 WP_059716974.1 NUDIX domain-containing protein -
WT26_RS21475 224443..224742 + 300 WP_069273897.1 helix-turn-helix domain-containing protein -
WT26_RS21480 224753..226105 + 1353 WP_069273898.1 aspartate aminotransferase family protein -
WT26_RS37455 226431..226985 + 555 WP_155123160.1 hypothetical protein -
WT26_RS36080 227173..227505 - 333 WP_010100491.1 helix-turn-helix domain-containing protein Antitoxin
WT26_RS21485 227498..227830 - 333 WP_069270810.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WT26_RS21490 228106..228726 + 621 WP_059479339.1 LysE family translocator -
WT26_RS21495 228797..229270 + 474 WP_069273899.1 cupin domain-containing protein -
WT26_RS21500 229284..230027 + 744 WP_155774685.1 SDR family oxidoreductase -
WT26_RS21505 230070..230375 - 306 WP_069273901.1 AzlD family protein -
WT26_RS21510 230368..231102 - 735 WP_069273902.1 AzlC family ABC transporter permease -
WT26_RS21515 231228..231686 + 459 WP_006749370.1 Lrp/AsnC family transcriptional regulator -
WT26_RS21520 231790..232359 + 570 WP_069273903.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(19-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(48-102)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12845.97 Da        Isoelectric Point: 10.4938

>T58679 WP_069270810.1 NZ_CP013444:c227830-227498 [Burkholderia cepacia]
MKIHWTIVYYYERVKRDVFAFPAGILANYLRLLDLMQEFGADLRMPHSRAMGNGLFELRPNGREGIGRVFYCTHVGRQVV
VLHSFVKKTQETPPQELRIAQARLREVRNG

Download         Length: 333 bp

>T58679 NZ_CP013444:c227830-227498 [Burkholderia cepacia]
ATGAAAATTCATTGGACGATCGTCTACTACTACGAACGCGTGAAGCGTGACGTTTTCGCGTTCCCCGCCGGGATTCTTGC
GAACTACCTTCGGCTGCTGGACCTGATGCAGGAATTCGGCGCAGATCTACGAATGCCTCACTCCCGCGCAATGGGTAACG
GGTTGTTCGAGTTGCGTCCAAACGGTAGGGAAGGTATCGGGCGAGTGTTCTATTGCACGCATGTGGGGCGGCAAGTCGTT
GTGCTGCACTCCTTCGTCAAGAAGACACAGGAGACGCCGCCGCAAGAATTGCGGATCGCCCAAGCACGTTTGAGAGAGGT
GCGGAATGGCTAA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 11724.35 Da        Isoelectric Point: 9.5722

>AT58679 WP_010100491.1 NZ_CP013444:c227505-227173 [Burkholderia cepacia]
MAKVATKRVRAEGFDPVPHTADDTARLLADGKVKAAYDALEDEYTALRALLAARQEAGLTQAQVAERMGTTASAVSRLEA
SLTSEKHSPSFATLRKYAAACGKRLVISFA

Download         Length: 333 bp

>AT58679 NZ_CP013444:c227505-227173 [Burkholderia cepacia]
ATGGCTAAGGTAGCAACGAAGCGTGTTCGCGCTGAGGGATTCGATCCGGTTCCGCATACGGCGGACGATACGGCTCGTCT
GCTCGCAGATGGCAAGGTCAAGGCGGCCTATGATGCGCTGGAAGATGAATACACCGCGCTGCGCGCACTATTGGCCGCGC
GGCAAGAGGCTGGACTGACTCAAGCACAGGTCGCTGAGCGCATGGGTACGACGGCGTCAGCCGTGTCGCGCCTCGAAGCA
TCGCTCACTAGCGAAAAGCATTCGCCCTCGTTTGCGACATTGCGAAAATATGCGGCCGCATGTGGCAAGAGGCTCGTGAT
TTCGTTTGCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4PXC5

Antitoxin

Source ID Structure
AlphaFold DB A0A0D0H342

References