Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 977859..978514 Replicon chromosome
Accession NZ_CP013443
Organism Burkholderia cepacia strain MSMB1184WGS

Toxin (Protein)


Gene name higB Uniprot ID A0A1B4PPS3
Locus tag WT26_RS07925 Protein ID WP_059590707.1
Coordinates 978170..978514 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1B4PPY9
Locus tag WT26_RS07920 Protein ID WP_059590709.1
Coordinates 977859..978173 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WT26_RS07895 973315..973752 - 438 WP_059529437.1 transcription antitermination factor NusB -
WT26_RS07900 973749..974270 - 522 WP_069272549.1 6,7-dimethyl-8-ribityllumazine synthase -
WT26_RS07905 974323..975465 - 1143 WP_059529440.1 bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II -
WT26_RS07910 975596..976114 - 519 WP_069273710.1 DUF1993 domain-containing protein -
WT26_RS07915 976458..977627 + 1170 WP_069269953.1 sensor domain-containing diguanylate cyclase -
WT26_RS07920 977859..978173 - 315 WP_059590709.1 XRE family transcriptional regulator Antitoxin
WT26_RS07925 978170..978514 - 345 WP_059590707.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WT26_RS07930 978828..979450 - 623 Protein_930 riboflavin synthase -
WT26_RS07935 979465..980586 - 1122 WP_069272550.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
WT26_RS07940 980602..981885 - 1284 WP_059529450.1 glutamate-1-semialdehyde 2,1-aminomutase -
WT26_RS07945 982028..982480 - 453 WP_069272551.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(45-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(45-90)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13410.31 Da        Isoelectric Point: 9.5311

>T58677 WP_059590707.1 NZ_CP013443:c978514-978170 [Burkholderia cepacia]
VHATFIELPPFSRERENYLADDEYAVLQKELLANPEAGDLIKGTGGLRKLRFADKRRQKGKRGGLRVIYYYWVSGYQFWL
FTLYDKDEMADLTSDERKAFAKLLEREVTIRSKQ

Download         Length: 345 bp

>T58677 NZ_CP013443:c978514-978170 [Burkholderia cepacia]
GTGCATGCGACCTTCATCGAACTGCCGCCATTTTCCCGTGAACGCGAGAACTACCTCGCGGATGATGAGTACGCCGTGCT
GCAGAAAGAGCTGCTGGCTAATCCCGAGGCCGGTGACTTGATCAAGGGAACCGGCGGTCTGCGGAAGCTGAGGTTCGCTG
ACAAACGTCGCCAGAAAGGCAAACGCGGTGGCCTACGAGTGATCTATTACTACTGGGTTAGCGGTTATCAATTCTGGTTG
TTCACGCTGTACGACAAGGATGAAATGGCAGACCTGACCAGTGACGAGCGGAAAGCCTTCGCGAAGCTACTGGAAAGAGA
GGTCACGATACGGAGCAAGCAATGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11660.53 Da        Isoelectric Point: 10.3374

>AT58677 WP_059590709.1 NZ_CP013443:c978173-977859 [Burkholderia cepacia]
MKKRNLFAELTEGLDALAAEREEKITLRKIKAEVPDALDVSPAEIKAVREASHASQAVMARSLRINVRTYQNWEQGKAKP
NAQAATLIRLVAKHPETLRMLETL

Download         Length: 315 bp

>AT58677 NZ_CP013443:c978173-977859 [Burkholderia cepacia]
ATGAAGAAGCGAAATCTGTTTGCTGAATTGACTGAGGGTCTCGACGCCCTTGCTGCCGAGCGCGAAGAGAAAATCACACT
GCGCAAGATCAAGGCCGAGGTGCCCGATGCGCTCGACGTTTCGCCGGCCGAAATCAAGGCCGTGCGCGAAGCATCTCACG
CATCTCAAGCTGTCATGGCTCGAAGCCTGCGCATCAACGTGCGCACGTATCAGAATTGGGAACAAGGCAAGGCCAAACCC
AACGCACAGGCCGCCACGCTGATCCGACTGGTCGCCAAGCACCCGGAAACGCTTCGGATGCTGGAAACGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4PPS3

Antitoxin

Source ID Structure
AlphaFold DB A0A1B4PPY9

References