Detailed information of TA system TA058654

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1301378..1302077
• Replicon: chromosome
• Accession: NZ_CP013431
• Organism: Burkholderia multivorans strain AU1185 isolate AU1185

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: WK22_RS21745
• Protein ID: WP_053298526.1
• Coordinates: 1301781..1302077 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: B9BI88
• Locus tag: WK22_RS21740
• Protein ID: WP_006403504.1
• Coordinates: 1301378..1301779 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WK22_RS21720	1297081..1298433	-	1353	WP_006409061.1	LLM class flavin-dependent oxidoreductase	-
WK22_RS21725	1298430..1299491	-	1062	WP_065496516.1	LLM class flavin-dependent oxidoreductase	-
WK22_RS21730	1299523..1300464	-	942	WP_069221063.1	ABC transporter substrate-binding protein	-
WK22_RS21735	1300529..1301089	-	561	WP_069221064.1	GNAT family N-acetyltransferase	-
WK22_RS21740	1301378..1301779	-	402	WP_006403504.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
WK22_RS21745	1301781..1302077	-	297	WP_053298526.1	type II toxin-antitoxin system MqsR family toxin	Toxin
WK22_RS21750	1302197..1303231	-	1035	WP_069221065.1	succinylglutamate desuccinylase/aspartoacylase family protein	-
WK22_RS21755	1303332..1303604	-	273	WP_006403506.1	hypothetical protein	-
WK22_RS21760	1303810..1305351	-	1542	WP_172820327.1	sensor domain-containing diguanylate cyclase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-97)

Antitoxin

• Antitoxin MqsA (3-131)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11173.06 Da
• Isoelectric Point: 9.1122

>T58654 WP_053298526.1 NZ_CP013431:c1302077-1301781 [Burkholderia multivorans]
MEKRTAHCKLPRVKALIEAGKVRLTASAVIGARQMGFTEAETIDVVRALTPFEFHKSMTTYADHTIWQDVYRPCTMRGDV
YLKLTVVDDVLIVSFKER

Nucleotide

• Length: 297 bp

>T58654 NZ_CP013431:c1302077-1301781 [Burkholderia multivorans]
ATGGAAAAGCGAACGGCGCACTGCAAGCTGCCGCGCGTCAAGGCGTTGATCGAAGCCGGCAAGGTCCGCCTGACCGCAAG
CGCCGTCATCGGCGCCCGCCAGATGGGCTTCACCGAAGCGGAAACCATCGACGTGGTGAGGGCGCTGACACCGTTCGAAT
TCCACAAGAGCATGACGACCTACGCCGACCACACGATCTGGCAGGACGTCTACCGGCCTTGCACGATGCGCGGCGACGTG
TACCTGAAACTGACCGTCGTCGACGATGTGCTGATCGTGTCTTTCAAGGAGCGATGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14521.68 Da
• Isoelectric Point: 7.0834

>AT58654 WP_006403504.1 NZ_CP013431:c1301779-1301378 [Burkholderia multivorans]
MKCPACGAATLVRDTRDIPYTYKGESTVIPHITGEFCPACGESVLDVDEATRFGEAVSAFNRQVNATLVDPKFIATVRKK
LKLDQREAAEIFGGGVNAFSRYETGKTNPPLALVKLLKILDRHPDLLDEVRAA

Nucleotide

• Length: 402 bp

>AT58654 NZ_CP013431:c1301779-1301378 [Burkholderia multivorans]
ATGAAATGTCCTGCATGCGGTGCTGCCACGCTGGTCCGCGACACGCGCGACATCCCGTACACCTACAAGGGCGAATCGAC
CGTGATCCCGCACATCACCGGCGAGTTTTGCCCCGCGTGCGGCGAGTCGGTGCTCGACGTCGACGAGGCGACCCGTTTCG
GCGAAGCGGTGTCGGCGTTCAACCGGCAGGTGAACGCGACACTCGTCGATCCGAAGTTCATTGCGACGGTACGCAAGAAG
CTGAAGCTCGATCAGCGCGAGGCGGCCGAGATTTTCGGCGGCGGCGTCAACGCGTTTTCCCGCTACGAGACCGGCAAGAC
CAATCCGCCGCTGGCGCTCGTGAAGCTGCTGAAGATTCTCGACCGTCATCCCGATCTGCTCGACGAAGTGCGTGCGGCAT
AA

Structures

Antitoxin

• AlphaFold DB: B9BI88