Detailed information of TA system TA058643

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1244462..1245162
• Replicon: chromosome
• Accession: NZ_CP013428
• Organism: Burkholderia sp. MSMB0856

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: WS87_RS23110
• Protein ID: WP_059819110.1
• Coordinates: 1244462..1244758 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: A0A102ESA9
• Locus tag: WS87_RS23115
• Protein ID: WP_059525531.1
• Coordinates: 1244761..1245162 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WS87_RS23095	1240989..1242539	+	1551	WP_059819107.1	sensor domain-containing diguanylate cyclase	-
WS87_RS23100	1242808..1243086	+	279	WP_059819108.1	hypothetical protein	-
WS87_RS23105	1243318..1244352	+	1035	WP_059819109.1	succinylglutamate desuccinylase/aspartoacylase family protein	-
WS87_RS23110	1244462..1244758	+	297	WP_059819110.1	type II toxin-antitoxin system MqsR family toxin	Toxin
WS87_RS23115	1244761..1245162	+	402	WP_059525531.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
WS87_RS23120	1245460..1246020	+	561	WP_059819111.1	GNAT family N-acetyltransferase	-
WS87_RS23125	1246084..1247025	+	942	WP_059819112.1	ABC transporter substrate-binding protein	-
WS87_RS23130	1247064..1248113	+	1050	WP_059819113.1	LLM class flavin-dependent oxidoreductase	-
WS87_RS23135	1248121..1249479	+	1359	WP_059819114.1	LLM class flavin-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (6-97)

Antitoxin

• Zinc finger, MqsA-type (3-48)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11149.77 Da
• Isoelectric Point: 8.0198

>T58643 WP_059819110.1 NZ_CP013428:1244462-1244758 [Burkholderia sp. MSMB0856]
MEKNAPHCKLSRVKTLIGTGNVRLTTSAVFGARQLGFTETEAIGVVMSLDTTDFYKSMTTYADHTIWQDVYRRRTENGDI
YLKLTVIDDVLIVSFKER

Nucleotide

• Length: 297 bp

>T58643 NZ_CP013428:1244462-1244758 [Burkholderia sp. MSMB0856]
ATGGAAAAGAACGCGCCTCATTGCAAGCTGTCGCGGGTCAAGACACTCATCGGGACCGGCAACGTCCGGTTGACGACGAG
CGCGGTGTTCGGGGCGCGGCAACTGGGTTTCACGGAAACGGAGGCGATCGGTGTCGTGATGTCCCTGGATACCACCGATT
TCTACAAAAGCATGACGACCTACGCCGATCACACGATCTGGCAGGACGTCTATCGGCGTCGCACCGAGAATGGCGACATA
TATCTGAAACTGACCGTGATCGACGACGTGCTGATCGTGTCGTTCAAGGAGCGATGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14566.86 Da
• Isoelectric Point: 8.4900

>AT58643 WP_059525531.1 NZ_CP013428:1244761-1245162 [Burkholderia sp. MSMB0856]
MKCPACGGAKLVRDTRDIPYTYKGRSTVVRDITGDFCPACGESVLDIDEATRLGEAIGEFNKQVNSTIVDPKFIAKVRKK
LMLDQREAAEIFGGGVNAFSRYETGKTNPPLALVKLLKILDRHPDLLAEVRAA

Nucleotide

• Length: 402 bp

>AT58643 NZ_CP013428:1244761-1245162 [Burkholderia sp. MSMB0856]
ATGAAGTGTCCTGCGTGCGGTGGCGCGAAACTGGTCCGCGATACACGAGACATCCCTTACACATACAAGGGTCGCTCGAC
CGTCGTTCGCGATATAACCGGCGACTTCTGTCCGGCCTGCGGCGAATCGGTGCTGGATATAGACGAGGCAACCCGGCTCG
GTGAAGCGATCGGCGAGTTCAACAAGCAAGTAAATTCGACCATCGTCGACCCGAAGTTCATCGCGAAGGTACGCAAGAAG
CTGATGCTGGATCAACGCGAGGCGGCCGAGATATTCGGTGGCGGCGTCAATGCTTTCTCGCGCTACGAAACCGGCAAGAC
GAACCCGCCGCTTGCCCTCGTGAAGTTGCTCAAGATTCTGGATCGTCATCCGGATCTGCTCGCGGAAGTACGCGCAGCCT
AG

Structures

Antitoxin

• AlphaFold DB: A0A102ESA9