Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 675175..675768 Replicon chromosome
Accession NZ_CP013416
Organism Burkholderia ubonensis strain MSMB2035

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag WJ32_RS22535 Protein ID WP_059759046.1
Coordinates 675490..675768 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag WJ32_RS22530 Protein ID WP_088501618.1
Coordinates 675175..675477 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WJ32_RS22505 670423..671694 + 1272 WP_059759037.1 Rieske 2Fe-2S domain-containing protein -
WJ32_RS22510 671709..672185 + 477 WP_059759040.1 aromatic-ring-hydroxylating dioxygenase subunit beta -
WJ32_RS22515 672205..672531 + 327 WP_045564530.1 non-heme iron oxygenase ferredoxin subunit -
WJ32_RS22520 672521..673741 + 1221 WP_059759042.1 FAD-dependent oxidoreductase -
WJ32_RS22525 673832..675118 + 1287 WP_059759044.1 DUF445 family protein -
WJ32_RS22530 675175..675477 - 303 WP_088501618.1 HigA family addiction module antidote protein Antitoxin
WJ32_RS22535 675490..675768 - 279 WP_059759046.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WJ32_RS22540 676146..676445 - 300 WP_059759048.1 putative addiction module antidote protein -
WJ32_RS22545 676449..676766 - 318 WP_059759050.1 type II toxin-antitoxin system RelE/ParE family toxin -
WJ32_RS22550 677180..678820 + 1641 WP_059759052.1 acetolactate synthase large subunit -
WJ32_RS22555 678850..680283 + 1434 WP_059759055.1 aldehyde dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-87)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10683.13 Da        Isoelectric Point: 7.8923

>T58619 WP_059759046.1 NZ_CP013416:c675768-675490 [Burkholderia ubonensis]
MIRSFRCKDTQSLFAGESPKRFRTIESVATRKLEMVAAAKELRDLRSPPGNRLEALHGNREGLHSIRINEQWRICFEWTD
DGPANVEILDYH

Download         Length: 279 bp

>T58619 NZ_CP013416:c675768-675490 [Burkholderia ubonensis]
ATGATCAGATCGTTCCGATGCAAAGATACCCAGTCGCTTTTCGCCGGCGAATCACCCAAGCGCTTCCGTACGATCGAATC
CGTTGCTACCCGGAAACTGGAAATGGTCGCTGCCGCGAAAGAACTGCGCGACTTGCGGTCTCCGCCCGGCAACCGGCTGG
AAGCGCTGCACGGCAATCGGGAAGGCCTGCACAGCATCCGTATCAATGAGCAATGGCGGATCTGCTTCGAATGGACCGAC
GACGGCCCTGCCAACGTCGAGATCCTTGACTATCACTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11615.36 Da        Isoelectric Point: 8.5562

>AT58619 WP_088501618.1 NZ_CP013416:c675477-675175 [Burkholderia ubonensis]
MLKNGMRPIHPGEILREEFLTPLEMSVNALALALNVPATRLHEIVKERRGVTADTAYRLARYFDTSPEFWLNLQATYDLK
TLPTRNEIDRKVEPRERTHA

Download         Length: 303 bp

>AT58619 NZ_CP013416:c675477-675175 [Burkholderia ubonensis]
ATGCTCAAGAATGGAATGCGTCCGATCCACCCGGGCGAAATCCTGCGAGAGGAATTCCTGACGCCGCTGGAGATGAGTGT
CAACGCGCTTGCACTCGCGTTGAACGTACCGGCTACCCGCCTGCATGAAATCGTCAAGGAACGGCGCGGAGTCACGGCCG
ATACCGCTTACCGGCTCGCACGCTACTTCGACACGTCACCCGAATTCTGGCTGAACCTGCAAGCCACGTACGACCTCAAA
ACGCTGCCGACGCGCAATGAGATCGATCGGAAGGTTGAACCGCGCGAACGCACGCACGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References