Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 193083..193740 Replicon chromosome
Accession NZ_CP013411
Organism Burkholderia thailandensis strain 2002721643

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AQ477_RS00865 Protein ID WP_045599895.1
Coordinates 193083..193415 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AQ477_RS30885 Protein ID WP_082255747.1
Coordinates 193408..193740 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AQ477_RS00840 188268..189194 + 927 WP_045599095.1 AAA family ATPase -
AQ477_RS00845 189191..190555 + 1365 WP_045599900.1 type II secretory pathway protein -
AQ477_RS00850 190569..190802 - 234 WP_045599897.1 hypothetical protein -
AQ477_RS00855 191327..192106 + 780 WP_045599896.1 hypothetical protein -
AQ477_RS00860 192454..193041 + 588 WP_045600852.1 site-specific integrase -
AQ477_RS00865 193083..193415 + 333 WP_045599895.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AQ477_RS30885 193408..193740 + 333 WP_082255747.1 helix-turn-helix domain-containing protein Antitoxin
AQ477_RS34760 193888..195396 + 1509 WP_045599894.1 hypothetical protein -
AQ477_RS00875 195706..196485 - 780 Protein_173 site-specific integrase -
AQ477_RS00880 196533..196730 - 198 WP_045599893.1 hypothetical protein -
AQ477_RS00885 196810..197097 + 288 Protein_175 phage portal protein -
AQ477_RS00890 197167..198387 - 1221 WP_025405302.1 ISL3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 184419..221199 36780


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(19-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(52-105)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12787.85 Da        Isoelectric Point: 10.1361

>T58612 WP_045599895.1 NZ_CP013411:193083-193415 [Burkholderia thailandensis]
MKLDWTVVYYNERVKRDVFAFPAGILADYLRLLDLMQEFGADLRMPHSRAMGNGLFELRPKGREGIGRVFYCTHVGQQVV
VLHSFVKKTQETPQHELRIAQARLREVRNG

Download         Length: 333 bp

>T58612 NZ_CP013411:193083-193415 [Burkholderia thailandensis]
ATGAAACTTGATTGGACGGTCGTCTACTACAACGAACGGGTGAAGCGCGACGTTTTTGCGTTCCCGGCTGGGATTCTTGC
GGACTACCTCCGGCTGTTGGATCTGATGCAGGAGTTCGGTGCGGATCTACGGATGCCGCACTCCCGAGCAATGGGTAACG
GGTTGTTTGAATTGCGTCCTAAGGGTAGGGAAGGTATCGGGCGGGTGTTCTATTGCACGCACGTGGGGCAGCAAGTCGTT
GTGCTGCACTCCTTCGTCAAGAAGACGCAGGAAACGCCGCAACATGAATTGCGGATCGCCCAAGCACGTTTGAGAGAGGT
ACGTAATGGCTAA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 11738.35 Da        Isoelectric Point: 10.4476

>AT58612 WP_082255747.1 NZ_CP013411:193408-193740 [Burkholderia thailandensis]
MAKAATKRVRADGFNPVPHTAEDTARLLAGRNVKAAYDALDDEYTALRAILSARRDAGLTQAQIAERMGTTASAVSRLEA
SLSSEKHSPSFATLRKYAAACGKRLVISFA

Download         Length: 333 bp

>AT58612 NZ_CP013411:193408-193740 [Burkholderia thailandensis]
ATGGCTAAGGCAGCAACGAAGCGCGTTCGCGCTGATGGATTCAATCCGGTTCCGCATACGGCGGAAGATACGGCACGTCT
GCTCGCCGGTCGCAATGTCAAGGCGGCGTATGACGCCCTGGACGATGAGTACACCGCGTTGCGAGCTATCTTGTCTGCAC
GGCGCGATGCTGGTCTGACGCAGGCTCAGATTGCGGAACGGATGGGTACGACCGCATCGGCGGTTTCGCGGCTTGAGGCT
TCGTTGTCGAGTGAAAAGCATTCACCATCATTTGCGACACTGCGTAAGTATGCGGCTGCATGTGGCAAGCGATTGGTTAT
CTCATTTGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References