Detailed information of TA system TA058612

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 193083..193740
• Replicon: chromosome
• Accession: NZ_CP013411
• Organism: Burkholderia thailandensis strain 2002721643

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: AQ477_RS00865
• Protein ID: WP_045599895.1
• Coordinates: 193083..193415 (+)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: AQ477_RS30885
• Protein ID: WP_082255747.1
• Coordinates: 193408..193740 (+)
• Length: 111 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AQ477_RS00840	188268..189194	+	927	WP_045599095.1	AAA family ATPase	-
AQ477_RS00845	189191..190555	+	1365	WP_045599900.1	type II secretory pathway protein	-
AQ477_RS00850	190569..190802	-	234	WP_045599897.1	hypothetical protein	-
AQ477_RS00855	191327..192106	+	780	WP_045599896.1	hypothetical protein	-
AQ477_RS00860	192454..193041	+	588	WP_045600852.1	site-specific integrase	-
AQ477_RS00865	193083..193415	+	333	WP_045599895.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AQ477_RS30885	193408..193740	+	333	WP_082255747.1	helix-turn-helix domain-containing protein	Antitoxin
AQ477_RS34760	193888..195396	+	1509	WP_045599894.1	hypothetical protein	-
AQ477_RS00875	195706..196485	-	780	Protein_173	site-specific integrase	-
AQ477_RS00880	196533..196730	-	198	WP_045599893.1	hypothetical protein	-
AQ477_RS00885	196810..197097	+	288	Protein_175	phage portal protein	-
AQ477_RS00890	197167..198387	-	1221	WP_025405302.1	ISL3 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	184419..221199	36780

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (19-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (52-105)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 12787.85 Da
• Isoelectric Point: 10.1361

>T58612 WP_045599895.1 NZ_CP013411:193083-193415 [Burkholderia thailandensis]
MKLDWTVVYYNERVKRDVFAFPAGILADYLRLLDLMQEFGADLRMPHSRAMGNGLFELRPKGREGIGRVFYCTHVGQQVV
VLHSFVKKTQETPQHELRIAQARLREVRNG

Nucleotide

• Length: 333 bp

>T58612 NZ_CP013411:193083-193415 [Burkholderia thailandensis]
ATGAAACTTGATTGGACGGTCGTCTACTACAACGAACGGGTGAAGCGCGACGTTTTTGCGTTCCCGGCTGGGATTCTTGC
GGACTACCTCCGGCTGTTGGATCTGATGCAGGAGTTCGGTGCGGATCTACGGATGCCGCACTCCCGAGCAATGGGTAACG
GGTTGTTTGAATTGCGTCCTAAGGGTAGGGAAGGTATCGGGCGGGTGTTCTATTGCACGCACGTGGGGCAGCAAGTCGTT
GTGCTGCACTCCTTCGTCAAGAAGACGCAGGAAACGCCGCAACATGAATTGCGGATCGCCCAAGCACGTTTGAGAGAGGT
ACGTAATGGCTAA

Antitoxin

Protein

• Length: 111 a.a.
• Molecular weight: 11738.35 Da
• Isoelectric Point: 10.4476

>AT58612 WP_082255747.1 NZ_CP013411:193408-193740 [Burkholderia thailandensis]
MAKAATKRVRADGFNPVPHTAEDTARLLAGRNVKAAYDALDDEYTALRAILSARRDAGLTQAQIAERMGTTASAVSRLEA
SLSSEKHSPSFATLRKYAAACGKRLVISFA

Nucleotide

• Length: 333 bp

>AT58612 NZ_CP013411:193408-193740 [Burkholderia thailandensis]
ATGGCTAAGGCAGCAACGAAGCGCGTTCGCGCTGATGGATTCAATCCGGTTCCGCATACGGCGGAAGATACGGCACGTCT
GCTCGCCGGTCGCAATGTCAAGGCGGCGTATGACGCCCTGGACGATGAGTACACCGCGTTGCGAGCTATCTTGTCTGCAC
GGCGCGATGCTGGTCTGACGCAGGCTCAGATTGCGGAACGGATGGGTACGACCGCATCGGCGGTTTCGCGGCTTGAGGCT
TCGTTGTCGAGTGAAAAGCATTCACCATCATTTGCGACACTGCGTAAGTATGCGGCTGCATGTGGCAAGCGATTGGTTAT
CTCATTTGCCTAA