Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 2786562..2787219 Replicon chromosome
Accession NZ_CP013377
Organism Burkholderia pseudomultivorans strain SUB-INT23-BP2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag WS57_RS12020 Protein ID WP_059516362.1
Coordinates 2786887..2787219 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag WS57_RS12015 Protein ID WP_059516208.1
Coordinates 2786562..2786894 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WS57_RS12005 2782500..2785532 + 3033 WP_069244259.1 hybrid sensor histidine kinase/response regulator -
WS57_RS37005 2785812..2786153 + 342 WP_059516206.1 SymE family type I addiction module toxin -
WS57_RS12015 2786562..2786894 - 333 WP_059516208.1 helix-turn-helix domain-containing protein Antitoxin
WS57_RS12020 2786887..2787219 - 333 WP_059516362.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WS57_RS12025 2787530..2788372 - 843 WP_059516210.1 peptidylprolyl isomerase -
WS57_RS12030 2788861..2789634 - 774 WP_155741181.1 glycosyltransferase family 25 protein -
WS57_RS12035 2789667..2789984 - 318 WP_059516214.1 hypothetical protein -
WS57_RS12040 2790582..2792066 + 1485 Protein_2448 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(18-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(52-105)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12796.84 Da        Isoelectric Point: 9.7738

>T58554 WP_059516362.1 NZ_CP013377:c2787219-2786887 [Burkholderia pseudomultivorans]
MKNWTILYYSERVKRDVFALPTGILAGYLRLIEMMEEYGADLRMPHSRAMGDGLFELRPRGREGVGRVFYCSQVGNELVI
LHSFVKKTQETPGDELRIAHRRMKEVRNHG

Download         Length: 333 bp

>T58554 NZ_CP013377:c2787219-2786887 [Burkholderia pseudomultivorans]
ATGAAGAACTGGACGATCCTGTATTACAGCGAACGTGTGAAGCGCGACGTATTTGCTTTGCCCACGGGCATTCTCGCGGG
CTACCTTCGTCTGATCGAAATGATGGAGGAATACGGCGCGGATCTACGGATGCCGCATTCGCGGGCGATGGGAGACGGAT
TGTTCGAATTGCGCCCGAGAGGCCGTGAAGGTGTCGGGCGCGTGTTTTATTGCTCGCAGGTGGGAAATGAACTCGTCATC
CTGCATTCCTTCGTCAAGAAGACGCAGGAAACGCCTGGCGACGAGCTACGCATTGCCCACCGGCGGATGAAGGAGGTTCG
CAACCATGGCTAA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 11886.45 Da        Isoelectric Point: 8.9539

>AT58554 WP_059516208.1 NZ_CP013377:c2786894-2786562 [Burkholderia pseudomultivorans]
MAKARSARAREDRYAPVRHTAEDTAGLLADPTLKAEYDALEEEFTALRALLDARKEAGLTQAQVAERMGTTTSAVSRLEA
SLSSEKHSPSFATLRKYAAACGKKLVISFA

Download         Length: 333 bp

>AT58554 NZ_CP013377:c2786894-2786562 [Burkholderia pseudomultivorans]
ATGGCTAAGGCCCGCTCCGCACGCGCCAGGGAGGACCGGTATGCACCGGTCCGACACACTGCCGAAGACACCGCCGGTCT
GCTCGCCGACCCCACCCTCAAGGCGGAATACGACGCGCTGGAAGAGGAATTCACCGCGCTTCGCGCGTTGCTGGACGCGC
GTAAAGAGGCAGGATTGACGCAGGCTCAGGTCGCCGAGCGAATGGGAACCACGACATCCGCCGTCTCCAGGCTCGAGGCC
TCGTTGTCGAGCGAAAAGCACTCGCCGTCGTTTGCGACGTTGCGCAAGTATGCCGCGGCGTGCGGGAAGAAGCTCGTCAT
TTCGTTTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References