Detailed information of TA system TA058549

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1492008..1492707
• Replicon: chromosome
• Accession: NZ_CP013377
• Organism: Burkholderia pseudomultivorans strain SUB-INT23-BP2

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: J4RFZ0
• Locus tag: WS57_RS06350
• Protein ID: WP_006413131.1
• Coordinates: 1492411..1492707 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: -
• Locus tag: WS57_RS06345
• Protein ID: WP_059517116.1
• Coordinates: 1492008..1492409 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WS57_RS06330	1488816..1490168	-	1353	WP_059517118.1	LLM class flavin-dependent oxidoreductase	-
WS57_RS06335	1490204..1491145	-	942	WP_040129168.1	ABC transporter substrate-binding protein	-
WS57_RS06340	1491199..1491759	-	561	WP_040129170.1	GNAT family N-acetyltransferase	-
WS57_RS06345	1492008..1492409	-	402	WP_059517116.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
WS57_RS06350	1492411..1492707	-	297	WP_006413131.1	type II toxin-antitoxin system MqsR family toxin	Toxin
WS57_RS06355	1492827..1493861	-	1035	WP_040129175.1	succinylglutamate desuccinylase/aspartoacylase family protein	-
WS57_RS06360	1494010..1494282	-	273	WP_009688345.1	hypothetical protein	-
WS57_RS06365	1494510..1496057	-	1548	WP_059605742.1	sensor domain-containing diguanylate cyclase	-
WS57_RS37555	1496002..1496304	-	303	WP_167361706.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-97)

Antitoxin

• Antitoxin MqsA (3-131)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11199.10 Da
• Isoelectric Point: 9.1122

>T58549 WP_006413131.1 NZ_CP013377:c1492707-1492411 [Burkholderia pseudomultivorans]
MEKRTPHCKLPRVKALIEAGKVRLTASAVIGARQMGFTEAETIDVVRALTPFEFHKSMTTYADHTIWQDVYRPCTMRGDV
YLKLTVVDDVLIVSFKER

Nucleotide

• Length: 297 bp

>T58549 NZ_CP013377:c1492707-1492411 [Burkholderia pseudomultivorans]
ATGGAAAAGAGAACGCCGCACTGCAAGCTGCCGCGCGTCAAGGCGCTGATCGAGGCCGGCAAGGTCCGCCTGACCGCAAG
CGCGGTCATCGGCGCCCGCCAGATGGGCTTCACCGAAGCGGAAACGATCGACGTGGTGAGGGCGCTGACACCGTTCGAAT
TCCACAAGAGCATGACGACCTACGCCGACCACACGATCTGGCAGGACGTCTACCGGCCTTGCACGATGCGCGGCGACGTG
TACCTGAAACTGACCGTCGTCGACGATGTGCTGATCGTGTCTTTCAAGGAGCGATGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14548.74 Da
• Isoelectric Point: 7.6700

>AT58549 WP_059517116.1 NZ_CP013377:c1492409-1492008 [Burkholderia pseudomultivorans]
MKCPACGAAKLIRDTRDIPYTYKGESTVIPHVTGEFCPACGESVLDVDEATRFGEAVSAFNRQVNATLVDPKFIATVRKK
LKLDQREAAEIFGGGVNAFSRYETGKTNPPLALVKLLKILDRHPDLLDEVRAA

Nucleotide

• Length: 402 bp

>AT58549 NZ_CP013377:c1492409-1492008 [Burkholderia pseudomultivorans]
ATGAAATGTCCTGCATGCGGTGCCGCCAAGCTGATCCGCGACACGCGCGACATCCCGTACACCTACAAGGGCGAATCGAC
CGTGATCCCGCACGTCACAGGCGAGTTTTGTCCCGCGTGCGGCGAGTCGGTGCTCGACGTCGACGAGGCGACCCGTTTCG
GCGAAGCGGTGTCGGCGTTCAACCGGCAAGTGAACGCGACGCTCGTCGATCCGAAGTTCATTGCGACGGTGCGCAAGAAG
CTGAAGCTCGATCAGCGCGAGGCGGCCGAGATTTTCGGCGGCGGCGTCAACGCGTTTTCCCGCTACGAGACCGGCAAGAC
CAATCCGCCGCTGGCGCTCGTGAAGCTGCTGAAGATTCTCGACCGTCATCCGGATCTGCTCGACGAAGTGCGCGCGGCAT
AA

Structures

Toxin

• AlphaFold DB: A0A132ERQ0