Detailed information of TA system TA058540

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1794368..1795068
• Replicon: chromosome
• Accession: NZ_CP013376
• Organism: Burkholderia cepacia strain INT3-BP177

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: A0A8E1VF58
• Locus tag: WI67_RS24645
• Protein ID: WP_048024629.1
• Coordinates: 1794368..1794664 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: A0A365QRC5
• Locus tag: WI67_RS24650
• Protein ID: WP_059861535.1
• Coordinates: 1794667..1795068 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WI67_RS24630	1790912..1792462	+	1551	WP_069255170.1	sensor domain-containing diguanylate cyclase	-
WI67_RS24635	1792706..1792981	+	276	WP_027791638.1	hypothetical protein	-
WI67_RS24640	1793224..1794264	+	1041	WP_059484890.1	succinylglutamate desuccinylase/aspartoacylase family protein	-
WI67_RS24645	1794368..1794664	+	297	WP_048024629.1	type II toxin-antitoxin system MqsR family toxin	Toxin
WI67_RS24650	1794667..1795068	+	402	WP_059861535.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
WI67_RS24655	1795386..1795946	+	561	WP_060226132.1	GNAT family N-acetyltransferase	-
WI67_RS24660	1796003..1796950	+	948	WP_021158756.1	ABC transporter substrate-binding protein	-
WI67_RS24665	1797019..1798068	+	1050	WP_069254544.1	LLM class flavin-dependent oxidoreductase	-
WI67_RS24670	1798076..1799428	+	1353	WP_069254545.1	LLM class flavin-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Antitoxin MqsA (3-131)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11236.04 Da
• Isoelectric Point: 8.9691

>T58540 WP_048024629.1 NZ_CP013376:1794368-1794664 [Burkholderia cepacia]
MEKRRPHCKLSLVKARVESGQVRLTASAVLGARQLGFTEREALDVVMSLTDLDFHKSMTTYADHTIWQDVYRPLTVRGDV
YLKLTVIDDVLIVSFKER

Nucleotide

• Length: 297 bp

>T58540 NZ_CP013376:1794368-1794664 [Burkholderia cepacia]
ATGGAAAAGAGAAGGCCTCATTGCAAGCTGTCCCTCGTCAAGGCGCGGGTCGAATCCGGCCAGGTCCGGTTGACCGCGAG
CGCGGTACTCGGCGCGCGGCAGCTCGGTTTCACGGAACGGGAGGCGCTCGATGTCGTGATGTCGCTGACCGACCTCGACT
TCCACAAGAGCATGACGACGTACGCCGACCACACGATCTGGCAGGACGTCTACCGGCCGTTGACGGTGCGCGGCGACGTG
TACCTGAAACTGACGGTGATCGACGATGTGCTGATCGTGTCTTTCAAGGAGCGATGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14572.81 Da
• Isoelectric Point: 8.4869

>AT58540 WP_059861535.1 NZ_CP013376:1794667-1795068 [Burkholderia cepacia]
MKCPACGAAKLVHDTRDIPYTYKGRSTVVRAITGEFCPACGESVLDLDEATRLGEAISEFNKQVNATIVDPNYIAKVRKK
LRLDQREAAELFGGGVNAFSRYETGKTNPPLALVKLLKILDRHPDLLAEVRAA

Nucleotide

• Length: 402 bp

>AT58540 NZ_CP013376:1794667-1795068 [Burkholderia cepacia]
ATGAAATGTCCTGCATGCGGTGCCGCGAAGCTGGTCCACGACACGCGCGACATCCCTTATACCTACAAGGGCCGGTCGAC
TGTCGTCCGCGCCATCACCGGCGAGTTCTGCCCGGCCTGCGGGGAATCGGTACTGGATCTCGACGAGGCGACCCGTCTCG
GCGAAGCGATCAGCGAGTTCAACAAGCAGGTGAACGCCACCATCGTCGACCCGAATTACATCGCGAAGGTACGCAAGAAG
CTGAGGCTCGACCAGCGCGAGGCGGCCGAGCTTTTCGGCGGCGGCGTCAACGCGTTCTCCCGTTACGAAACAGGCAAGAC
GAATCCGCCGCTTGCCCTCGTGAAACTGCTGAAGATCCTCGATCGTCACCCCGATCTGCTCGCCGAAGTCCGGGCGGCAT
AG

Structures

Antitoxin

• AlphaFold DB: A0A365QRC5