58515

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 709625..710218 Replicon chromosome
Accession NZ_CP013371
Organism Burkholderia ubonensis strain RF23-BP41

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag WI31_RS24765 Protein ID WP_059654532.1
Coordinates 709940..710218 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag WI31_RS24760 Protein ID WP_088501618.1
Coordinates 709625..709927 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WI31_RS24735 704872..706143 + 1272 WP_059654471.1 Rieske 2Fe-2S domain-containing protein -
WI31_RS24740 706158..706634 + 477 WP_059618175.1 aromatic-ring-hydroxylating dioxygenase subunit beta -
WI31_RS24745 706654..706980 + 327 WP_059654469.1 non-heme iron oxygenase ferredoxin subunit -
WI31_RS24750 706970..708190 + 1221 WP_059618177.1 FAD-dependent oxidoreductase -
WI31_RS24755 708282..709568 + 1287 WP_059654468.1 DUF445 family protein -
WI31_RS24760 709625..709927 - 303 WP_088501618.1 HigA family addiction module antidote protein Antitoxin
WI31_RS24765 709940..710218 - 279 WP_059654532.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WI31_RS24770 710601..710900 - 300 WP_010089041.1 putative addiction module antidote protein -
WI31_RS24775 710904..711221 - 318 WP_059654467.1 type II toxin-antitoxin system RelE/ParE family toxin -
WI31_RS24780 711664..713304 + 1641 WP_059618185.1 acetolactate synthase large subunit -
WI31_RS24785 713334..714767 + 1434 WP_059618187.1 aldehyde dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-87)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10654.04 Da        Isoelectric Point: 7.8922

>T58515 WP_059654532.1 NZ_CP013371:c710218-709940 [Burkholderia ubonensis]
MIRSFRCKDTQSLFAGESPKRFRTIESVAARKLEMVAAAKELRDLRSPPGNRLEALHGNRDGQHSIRINEQWRICFEWTD
DGPANVEILDYH

Download         Length: 279 bp

>T58515 NZ_CP013371:c710218-709940 [Burkholderia ubonensis]
ATGATCAGATCGTTCCGATGCAAAGATACCCAGTCGCTTTTCGCCGGCGAATCACCCAAACGCTTCCGTACGATCGAATC
CGTTGCTGCCCGGAAACTGGAAATGGTCGCTGCTGCGAAAGAACTGCGCGACTTGCGGTCTCCGCCCGGCAACCGGCTGG
AAGCGCTGCACGGCAATCGGGATGGCCAGCACAGCATCCGTATCAATGAGCAATGGCGGATCTGCTTCGAGTGGACCGAC
GACGGCCCCGCCAACGTCGAGATCCTTGACTATCACTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11615.36 Da        Isoelectric Point: 8.5562

>AT58515 WP_088501618.1 NZ_CP013371:c709927-709625 [Burkholderia ubonensis]
MLKNGMRPIHPGEILREEFLTPLEMSVNALALALNVPATRLHEIVKERRGVTADTAYRLARYFDTSPEFWLNLQATYDLK
TLPTRNEIDRKVEPRERTHA

Download         Length: 303 bp

>AT58515 NZ_CP013371:c709927-709625 [Burkholderia ubonensis]
ATGCTCAAGAATGGAATGCGTCCGATCCACCCGGGCGAAATCCTGCGAGAGGAATTCCTGACGCCGCTGGAGATGAGTGT
CAACGCGCTTGCACTCGCGTTGAACGTACCGGCTACCCGCCTGCATGAAATCGTCAAGGAACGGCGCGGGGTCACGGCCG
ATACCGCTTACCGGCTCGCACGCTACTTCGACACGTCACCCGAATTCTGGCTGAACCTGCAAGCCACGTACGACCTCAAA
ACGCTGCCGACGCGCAATGAGATCGACCGGAAGGTTGAACCGCGCGAACGCACGCACGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References