Detailed information of TA system TA058504

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 157274..157793
• Replicon: chromosome
• Accession: NZ_CP013365
• Organism: Burkholderia territorii strain RF8-non-BP5

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: WS51_RS00760
• Protein ID: WP_081053883.1
• Coordinates: 157548..157793 (-)
• Length: 82 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A119ANB3
• Locus tag: WS51_RS00755
• Protein ID: WP_059508080.1
• Coordinates: 157274..157561 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WS51_RS00725	152692..153495	+	804	WP_059447565.1	SDR family oxidoreductase	-
WS51_RS00730	153687..154466	-	780	WP_069228429.1	5'/3'-nucleotidase SurE	-
WS51_RS00735	154668..154967	-	300	WP_069229092.1	AzlD family protein	-
WS51_RS00740	154960..155697	-	738	WP_069228430.1	AzlC family ABC transporter permease	-
WS51_RS00745	155824..156282	+	459	WP_059447568.1	Lrp/AsnC family transcriptional regulator	-
WS51_RS00750	156501..157070	+	570	WP_059508079.1	hypothetical protein	-
WS51_RS00755	157274..157561	-	288	WP_059508080.1	helix-turn-helix domain-containing protein	Antitoxin
WS51_RS00760	157548..157793	-	246	WP_081053883.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
WS51_RS00765	157852..158712	-	861	WP_069228432.1	hypothetical protein	-
WS51_RS00770	158775..159107	-	333	WP_059447572.1	DUF2322 family protein	-
WS51_RS00775	159152..159844	-	693	WP_069229093.1	flavin reductase family protein	-
WS51_RS00780	160082..160408	+	327	WP_059447574.1	thioredoxin family protein	-
WS51_RS00785	160416..160835	+	420	WP_059447640.1	secondary thiamine-phosphate synthase enzyme YjbQ	-
WS51_RS00790	160892..162703	-	1812	WP_059447575.1	hybrid sensor histidine kinase/response regulator AtsR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (7-74)

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-90)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9372.99 Da
• Isoelectric Point: 11.0556

>T58504 WP_081053883.1 NZ_CP013365:c157793-157548 [Burkholderia territorii]
MRSLSRRNGANLGEPHTWSMGNGLYEMRLKGAEGIARVFYCAIVERRIVMLHCFVKKTQKTPRKELQIARQRLKEVQDGN
V

Nucleotide

• Length: 246 bp

>T58504 NZ_CP013365:c157793-157548 [Burkholderia territorii]
ATGCGTTCGTTGTCGCGGCGAAACGGCGCGAATCTCGGCGAGCCGCACACCTGGTCGATGGGAAACGGGCTGTACGAAAT
GCGACTGAAGGGCGCCGAAGGCATCGCCCGGGTGTTCTACTGCGCGATCGTCGAGCGGCGTATCGTCATGCTGCATTGTT
TCGTGAAGAAGACGCAAAAGACGCCGCGCAAGGAATTGCAAATCGCACGGCAACGACTCAAGGAGGTTCAAGATGGCAAC
GTATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10424.00 Da
• Isoelectric Point: 8.9919

>AT58504 WP_059508080.1 NZ_CP013365:c157561-157274 [Burkholderia territorii]
MATYKALRERALSNPEVHAEYERLNREELALLDMMLAARRDAGLSQADVAERMGTQAPAVTRLERALATGQHSPSIDTLR
KYAAACGKKLVISLA

Nucleotide

• Length: 288 bp

>AT58504 NZ_CP013365:c157561-157274 [Burkholderia territorii]
ATGGCAACGTATAAGGCGCTACGCGAGCGTGCCTTGTCCAACCCCGAGGTGCACGCCGAATACGAGCGGCTCAACCGCGA
AGAACTCGCACTGCTCGACATGATGCTGGCTGCCCGGCGAGACGCCGGCCTGTCGCAAGCCGATGTAGCCGAGCGCATGG
GCACGCAAGCACCGGCGGTGACGCGGCTCGAGCGCGCGCTCGCAACGGGCCAGCATTCACCGTCCATCGACACGCTGCGC
AAGTACGCGGCAGCTTGCGGCAAGAAACTCGTGATCTCGCTCGCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A119ANB3