Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 225771..226428 Replicon chromosome
Accession NZ_CP013357
Organism Burkholderia oklahomensis EO147

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag WG70_RS15295 Protein ID WP_010111813.1
Coordinates 225771..226103 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag WG70_RS15300 Protein ID WP_010111811.1
Coordinates 226111..226428 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WG70_RS15275 221414..222778 + 1365 WP_038802797.1 type II secretory pathway protein -
WG70_RS15280 223088..223564 + 477 WP_038802796.1 hypothetical protein -
WG70_RS15285 224015..224794 + 780 WP_038801760.1 hypothetical protein -
WG70_RS15290 225142..225729 + 588 WP_038801761.1 site-specific integrase -
WG70_RS15295 225771..226103 + 333 WP_010111813.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WG70_RS15300 226111..226428 + 318 WP_010111811.1 helix-turn-helix domain-containing protein Antitoxin
WG70_RS15305 226628..226933 + 306 WP_081464427.1 DUF3892 domain-containing protein -
WG70_RS15315 227215..228537 - 1323 WP_038802795.1 IS5 family transposase -
WG70_RS15320 228686..229708 - 1023 WP_081956034.1 site-specific integrase -
WG70_RS15330 229732..230760 + 1029 WP_038802586.1 IS21 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 216671..248967 32296


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(19-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-97)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12863.95 Da        Isoelectric Point: 10.3619

>T58492 WP_010111813.1 NZ_CP013357:225771-226103 [Burkholderia oklahomensis EO147]
MKFDWTIVYYNERVKRDVFAFPAGILADYLRLLDLMQEFGADLRMPHSRAMGNGLFELRPKGREGIGRVFYCTHVGRQVV
VLHSFVKKTQETPQHELRIAQARLREVRNG

Download         Length: 333 bp

>T58492 NZ_CP013357:225771-226103 [Burkholderia oklahomensis EO147]
ATGAAATTCGATTGGACGATTGTCTACTATAACGAACGGGTGAAGCGCGACGTGTTCGCGTTCCCGGCAGGGATTCTCGC
GGACTACCTCCGGCTGTTGGATCTGATGCAGGAGTTCGGGGCAGATCTGCGGATGCCGCACTCCCGAGCAATGGGTAACG
GGTTGTTTGAGTTGCGCCCCAAGGGGAGGGAAGGTATCGGTCGAGTGTTCTATTGCACGCATGTGGGGCGGCAAGTCGTT
GTGCTGCACTCCTTCGTTAAGAAGACACAGGAAACACCGCAACATGAATTGCGGATCGCCCAAGCACGTTTAAGAGAGGT
GCGTAATGGCTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11235.76 Da        Isoelectric Point: 10.2231

>AT58492 WP_010111811.1 NZ_CP013357:226111-226428 [Burkholderia oklahomensis EO147]
VKRARAEGFNPVPHTADDTARLLAGRNVKAAYDALEDEYTALRAILSARREAGLTQAQIAERMGTTASAVSRLEASLSSE
KHSPSFATLRKYAAACGKKLVISFA

Download         Length: 318 bp

>AT58492 NZ_CP013357:226111-226428 [Burkholderia oklahomensis EO147]
GTGAAGCGTGCTCGCGCTGAGGGATTCAATCCGGTTCCGCATACGGCGGACGACACGGCGCGTCTGCTCGCCGGTCGGAA
TGTCAAGGCGGCGTATGACGCTTTGGAGGATGAGTACACCGCGTTGCGCGCTATCTTGTCTGCGCGGCGCGAAGCTGGTT
TGACGCAGGCACAGATTGCGGAGCGTATGGGAACGACCGCATCGGCGGTTTCGCGGCTTGAGGCATCTCTGTCGAGTGAA
AAGCACTCACCGTCATTTGCGACGCTGCGGAAATATGCTGCCGCATGCGGGAAGAAACTTGTAATTTCGTTTGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References