Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 218546..219055 Replicon chromosome
Accession NZ_CP013355
Organism Lutibacter profundi strain LP1

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0X8G4I1
Locus tag Lupro_RS01010 Protein ID WP_068205639.1
Coordinates 218795..219055 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0X8G4K4
Locus tag Lupro_RS01005 Protein ID WP_068205638.1
Coordinates 218546..218794 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Lupro_RS00985 214017..214862 + 846 WP_068205634.1 transketolase -
Lupro_RS00990 214972..216105 + 1134 WP_068205635.1 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA -
Lupro_RS00995 216173..217696 + 1524 WP_068205636.1 hypothetical protein -
Lupro_RS01000 217703..218290 + 588 WP_144439088.1 hypothetical protein -
Lupro_RS01005 218546..218794 + 249 WP_068205638.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
Lupro_RS01010 218795..219055 + 261 WP_068205639.1 Txe/YoeB family addiction module toxin Toxin
Lupro_RS13405 219127..219210 + 84 Protein_198 transposase -
Lupro_RS01020 219433..220500 - 1068 WP_068205641.1 3-dehydroquinate synthase -
Lupro_RS01025 220585..221751 + 1167 WP_068205642.1 proline dehydrogenase family protein -
Lupro_RS01030 221911..222597 - 687 WP_068205643.1 Crp/Fnr family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10357.99 Da        Isoelectric Point: 9.7876

>T58488 WP_068205639.1 NZ_CP013355:218795-219055 [Lutibacter profundi]
MKLTWSTSSWEDYLYWQKVDKKIVIRINELIKSCIRTPFEGIGKPEALKGDLRGYWSRRITSEHRLVYKYDNEQILIAAC
RYHYGK

Download         Length: 261 bp

>T58488 NZ_CP013355:218795-219055 [Lutibacter profundi]
ATGAAATTAACTTGGTCTACTTCTTCTTGGGAAGATTATTTGTATTGGCAGAAAGTCGATAAGAAAATAGTAATACGAAT
TAACGAACTCATTAAAAGCTGTATACGAACACCTTTTGAAGGTATAGGAAAACCAGAAGCTTTAAAGGGAGATTTACGAG
GTTATTGGTCAAGGCGAATAACATCAGAACATCGATTGGTTTACAAATACGATAATGAACAAATCTTGATAGCAGCTTGT
CGTTATCATTATGGAAAATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9531.88 Da        Isoelectric Point: 5.1283

>AT58488 WP_068205638.1 NZ_CP013355:218546-218794 [Lutibacter profundi]
METVNYTDFRSNLKHWFDKVVNDVSDIIIKRKSGKDLVLISLDEYNSLKETTYLLTGKNRDILLNSIKELEADKGVQKDL
IE

Download         Length: 249 bp

>AT58488 NZ_CP013355:218546-218794 [Lutibacter profundi]
ATGGAAACAGTTAATTATACAGACTTTCGTTCAAATCTAAAGCATTGGTTTGATAAAGTAGTCAATGATGTAAGCGATAT
CATTATCAAGCGTAAAAGCGGTAAAGACCTTGTTTTAATATCATTAGATGAATACAACTCATTAAAGGAAACTACATATT
TACTAACAGGAAAAAATAGAGATATTTTATTAAACTCTATCAAAGAACTGGAAGCAGATAAAGGTGTTCAAAAAGACTTA
ATAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X8G4I1

Antitoxin

Source ID Structure
AlphaFold DB A0A0X8G4K4

References