Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/MqsA(antitoxin)
Location 2354480..2355148 Replicon chromosome
Accession NZ_CP013348
Organism Paraburkholderia caribensis strain Bcrs1W

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ATN79_RS26680 Protein ID WP_062917048.1
Coordinates 2354807..2355148 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ATN79_RS26675 Protein ID WP_060605496.1
Coordinates 2354480..2354791 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ATN79_RS26665 2350750..2352033 + 1284 WP_054933746.1 4-aminobutyrate--2-oxoglutarate transaminase -
ATN79_RS26670 2352919..2354385 + 1467 WP_054933743.1 NAD-dependent succinate-semialdehyde dehydrogenase -
ATN79_RS26675 2354480..2354791 - 312 WP_060605496.1 helix-turn-helix domain-containing protein Antitoxin
ATN79_RS26680 2354807..2355148 - 342 WP_062917048.1 hypothetical protein Toxin
ATN79_RS26685 2355405..2356379 - 975 WP_062917049.1 lipoyl synthase -
ATN79_RS26690 2356382..2357494 - 1113 WP_054933739.1 acetoin dehydrogenase dihydrolipoyllysine-residue acetyltransferase subunit -
ATN79_RS26695 2357510..2358514 - 1005 WP_062917050.1 alpha-ketoacid dehydrogenase subunit beta -
ATN79_RS26700 2358553..2359530 - 978 WP_054933738.1 thiamine pyrophosphate-dependent dehydrogenase E1 component subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(41-87)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13186.17 Da        Isoelectric Point: 9.8724

>T58485 WP_062917048.1 NZ_CP013348:c2355148-2354807 [Paraburkholderia caribensis]
MAATFVELGPFRRWRDDYLTDDEYRALQIMLMQNPEAGDVIRGTGGLRKLRFGDARRGKGKRGGLRVIYYYWVKGPEFWM
FTLYDKDEAEDLSSKGRGVLSEMLREVIKLANR

Download         Length: 342 bp

>T58485 NZ_CP013348:c2355148-2354807 [Paraburkholderia caribensis]
ATGGCGGCGACTTTCGTCGAGCTAGGCCCATTTCGCCGGTGGCGGGACGACTATCTGACGGACGACGAATATCGCGCGCT
TCAGATTATGCTGATGCAGAACCCAGAAGCAGGGGATGTCATCAGGGGAACGGGTGGGCTGCGCAAACTCCGTTTCGGCG
ACGCACGGCGCGGGAAGGGAAAGCGCGGCGGGCTCAGGGTGATCTACTACTACTGGGTAAAGGGCCCCGAGTTCTGGATG
TTCACGCTGTACGACAAGGACGAAGCTGAAGACCTGTCGTCGAAGGGACGAGGGGTTCTCTCCGAGATGCTGAGAGAAGT
CATCAAGCTTGCGAATCGATAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11827.65 Da        Isoelectric Point: 9.7238

>AT58485 WP_060605496.1 NZ_CP013348:c2354791-2354480 [Paraburkholderia caribensis]
MKRNLLAELTEGLEELKSAHEGKTTLHKVKVEIRDKLEVTAEEIRAVRESINASQAVMARRLRVNERTYQNWEQGRAKPN
AQAAVLIKLVEKHPETIQMLETL

Download         Length: 312 bp

>AT58485 NZ_CP013348:c2354791-2354480 [Paraburkholderia caribensis]
ATGAAACGGAATCTGTTAGCCGAATTGACGGAAGGGCTCGAAGAACTCAAGTCCGCTCACGAAGGCAAGACCACACTTCA
CAAGGTCAAGGTTGAGATTCGTGACAAGCTGGAAGTAACGGCCGAGGAGATCCGTGCCGTCCGCGAATCCATCAACGCGT
CACAGGCGGTCATGGCACGCCGTCTGCGCGTGAACGAGCGGACCTACCAGAATTGGGAGCAAGGGCGGGCGAAACCGAAC
GCTCAGGCTGCCGTGCTGATCAAGCTGGTTGAAAAGCATCCTGAGACGATCCAGATGCTCGAAACCTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References