Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 383781..384396 | Replicon | chromosome |
| Accession | NZ_CP013308 | ||
| Organism | Vibrio cholerae strain E506 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q9KMG5 |
| Locus tag | ASZ84_RS16105 | Protein ID | WP_001162670.1 |
| Coordinates | 383781..384068 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | ASZ84_RS16110 | Protein ID | WP_001232701.1 |
| Coordinates | 384079..384396 (+) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ASZ84_RS20015 | 379066..379176 | + | 111 | Protein_366 | DUF3265 domain-containing protein | - |
| ASZ84_RS20430 | 379417..379512 | + | 96 | WP_001907607.1 | DUF645 family protein | - |
| ASZ84_RS16060 | 379706..380023 | - | 318 | WP_001180243.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| ASZ84_RS16065 | 380042..380284 | - | 243 | WP_000557292.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| ASZ84_RS16070 | 380526..381035 | + | 510 | WP_000405987.1 | GNAT family N-acetyltransferase | - |
| ASZ84_RS16075 | 381092..381745 | + | 654 | WP_000226874.1 | hypothetical protein | - |
| ASZ84_RS16080 | 382055..382273 | + | 219 | WP_001917086.1 | DUF3709 domain-containing protein | - |
| ASZ84_RS16090 | 382676..382909 | + | 234 | WP_032482776.1 | DUF3709 domain-containing protein | - |
| ASZ84_RS16095 | 383334..383514 | + | 181 | Protein_374 | DUF645 family protein | - |
| ASZ84_RS16105 | 383781..384068 | + | 288 | WP_001162670.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| ASZ84_RS16110 | 384079..384396 | + | 318 | WP_001232701.1 | HigA family addiction module antidote protein | Antitoxin |
| ASZ84_RS20435 | 384393..384503 | + | 111 | WP_134814058.1 | DUF3265 domain-containing protein | - |
| ASZ84_RS20440 | 384680..384805 | + | 126 | WP_001944767.1 | DUF645 family protein | - |
| ASZ84_RS20445 | 384821..384859 | + | 39 | WP_106019119.1 | hypothetical protein | - |
| ASZ84_RS16130 | 385083..385823 | + | 741 | WP_000469836.1 | PhzF family phenazine biosynthesis protein | - |
| ASZ84_RS16135 | 386028..386858 | + | 831 | WP_000056616.1 | abortive infection family protein | - |
| ASZ84_RS16140 | 386915..387397 | + | 483 | WP_001895003.1 | hypothetical protein | - |
| ASZ84_RS16150 | 387844..388719 | + | 876 | WP_000259044.1 | hypothetical protein | - |
| ASZ84_RS16155 | 388849..389304 | + | 456 | WP_001245327.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 304088..451655 | 147567 | |
| - | inside | Integron | - | - | 309168..451279 | 142111 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11349.95 Da Isoelectric Point: 6.7187
>T58289 WP_001162670.1 NZ_CP013308:383781-384068 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
Download Length: 288 bp
>T58289 NZ_CP013308:383781-384068 [Vibrio cholerae]
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11705.63 Da Isoelectric Point: 10.4711
>AT58289 WP_001232701.1 NZ_CP013308:384079-384396 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART
Download Length: 318 bp
>AT58289 NZ_CP013308:384079-384396 [Vibrio cholerae]
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTCAGTAATTTAATTAATGGTGGTGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCCGCGGCATTAGGTAACACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTCAGTAATTTAATTAATGGTGGTGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCCGCGGCATTAGGTAACACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|