Detailed information of TA system TA058180

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 4331131..4331806
• Replicon: chromosome
• Accession: NZ_CP013236
• Organism: Collimonas pratensis strain Ter291

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: CPter291_RS19420
• Protein ID: WP_197481599.1
• Coordinates: 4331432..4331806 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A127R352
• Locus tag: CPter291_RS19415
• Protein ID: WP_041742396.1
• Coordinates: 4331131..4331415 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CPter291_RS19410	4329199..4330734	-	1536	WP_062118202.1	hypothetical protein	-
CPter291_RS19415	4331131..4331415	-	285	WP_041742396.1	helix-turn-helix domain-containing protein	Antitoxin
CPter291_RS19420	4331432..4331806	-	375	WP_197481599.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CPter291_RS19425	4332060..4332422	-	363	WP_062118205.1	hypothetical protein	-
CPter291_RS19430	4332836..4333843	-	1008	WP_062121080.1	DUF475 domain-containing protein	-
CPter291_RS19435	4334277..4335233	-	957	WP_062118208.1	OmpA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (30-117)

Antitoxin

• Cro/C1-type helix-turn-helix domain (32-90)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 14386.05 Da
• Isoelectric Point: 10.4915

>T58180 WP_197481599.1 NZ_CP013236:c4331806-4331432 [Collimonas pratensis]
MRLQKSTSNCNKYVMIEYQVSYYSQQIQADIMSLPATLQARYLSLTARMKIYGPHLGEPHTKMLGNGLLELRLKGAEGIA
RVFYCTMAGKQIVMLHSFVKKTQKIPFKEKRIAEIRMREVKNER

Nucleotide

• Length: 375 bp

>T58180 NZ_CP013236:c4331806-4331432 [Collimonas pratensis]
ATGAGATTACAGAAATCCACGTCAAATTGTAACAAATATGTTATGATTGAATATCAGGTTAGTTACTATAGCCAACAGAT
CCAGGCAGACATTATGTCCTTGCCGGCAACGCTGCAGGCACGCTATCTCAGCTTGACCGCCAGAATGAAGATTTACGGCC
CTCATTTGGGGGAGCCTCATACCAAGATGCTTGGCAATGGCTTGCTTGAGTTACGCTTGAAGGGCGCGGAAGGCATTGCC
CGTGTTTTTTATTGCACGATGGCCGGGAAGCAGATTGTCATGTTGCACAGTTTCGTCAAGAAGACACAAAAAATTCCTTT
TAAGGAAAAACGGATTGCAGAAATTCGCATGAGGGAAGTTAAAAATGAGCGCTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10397.00 Da
• Isoelectric Point: 9.7320

>AT58180 WP_041742396.1 NZ_CP013236:c4331415-4331131 [Collimonas pratensis]
MTHEEMQARMLQNPVVQAEYERLNREEFAILDEILAARKAAGLTQAQIAERMGTKAPAVARLESSLASGKHSPSINTLRK
YAAALGKRLEVHLV

Nucleotide

• Length: 285 bp

>AT58180 NZ_CP013236:c4331415-4331131 [Collimonas pratensis]
ATGACGCATGAAGAAATGCAGGCTCGGATGCTGCAGAATCCCGTTGTCCAGGCTGAATACGAACGCTTGAATCGCGAAGA
GTTTGCCATTCTTGACGAAATTTTAGCGGCACGCAAAGCGGCTGGACTCACCCAGGCACAGATTGCCGAGCGTATGGGAA
CCAAGGCGCCAGCCGTGGCGCGCCTGGAAAGTTCATTAGCTTCGGGTAAGCACTCTCCTAGCATCAATACATTACGCAAA
TATGCGGCAGCGCTTGGAAAACGCCTCGAAGTGCATCTGGTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A127R352