Detailed information of TA system TA058175

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1335594..1336309
• Replicon: chromosome
• Accession: NZ_CP013236
• Organism: Collimonas pratensis strain Ter291

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: CPter291_RS06035
• Protein ID: WP_062112804.1
• Coordinates: 1336013..1336309 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: A0A127QV01
• Locus tag: CPter291_RS06030
• Protein ID: WP_062112801.1
• Coordinates: 1335594..1336010 (-)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CPter291_RS06000	1330628..1331899	-	1272	WP_062112788.1	M48 family metallopeptidase	-
CPter291_RS06005	1332106..1332711	+	606	WP_061938183.1	oligoribonuclease	-
CPter291_RS06010	1332771..1333481	-	711	WP_062112790.1	UPF0149 family protein	-
CPter291_RS06015	1333625..1334134	+	510	WP_062112793.1	GNAT family N-acetyltransferase	-
CPter291_RS06020	1334163..1335035	-	873	WP_062112796.1	DNA ligase	-
CPter291_RS06025	1335127..1335513	-	387	WP_062112798.1	diguanylate cyclase	-
CPter291_RS06030	1335594..1336010	-	417	WP_062112801.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
CPter291_RS06035	1336013..1336309	-	297	WP_062112804.1	type II toxin-antitoxin system MqsR family toxin	Toxin
CPter291_RS06040	1336468..1337460	+	993	WP_062112807.1	serine/threonine protein kinase	-
CPter291_RS06045	1337479..1337808	-	330	WP_061938204.1	multidrug efflux SMR transporter	-
CPter291_RS06050	1337872..1338768	-	897	WP_061938207.1	LysR family transcriptional regulator	-
CPter291_RS06055	1338914..1340278	+	1365	WP_062112810.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1333625..1354980	21355

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (74-127)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11026.90 Da
• Isoelectric Point: 6.8597

>T58175 WP_062112804.1 NZ_CP013236:c1336309-1336013 [Collimonas pratensis]
MEKRTPHCHLSIVKTLVEVGQVCTTKSAREGAVGLGLDFDAMLEVVMALSSADFYKSMTSHADHRVWQDVYRPITPFGKI
YLKLTVIDELLIVSFKEL

Nucleotide

• Length: 297 bp

>T58175 NZ_CP013236:c1336309-1336013 [Collimonas pratensis]
ATGGAAAAACGAACGCCCCACTGCCATTTATCCATTGTCAAAACTTTGGTTGAGGTAGGGCAAGTGTGTACGACCAAAAG
CGCCCGCGAAGGAGCTGTTGGACTGGGGCTGGATTTCGACGCCATGCTTGAGGTAGTCATGGCGCTGAGTTCTGCCGATT
TTTACAAGAGCATGACTAGCCATGCGGATCATCGGGTATGGCAGGACGTATACAGGCCGATTACTCCATTTGGCAAGATC
TACCTGAAACTGACGGTGATTGATGAATTACTCATCGTGTCATTCAAGGAACTCTGA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 14993.24 Da
• Isoelectric Point: 8.1307

>AT58175 WP_062112801.1 NZ_CP013236:c1336010-1335594 [Collimonas pratensis]
MKCPTCGAAELARDTRLMPYTYKGESTTIPAVSGEYCPACGEAILDAAESRRTMKLMNEFNKHVNAASVDPAFITNVRKK
LALDQREAAEIFGGGVNAFSRYENGKSKPSVALVKLLQLLDRHPDLLAEIRTVHAAPA

Nucleotide

• Length: 417 bp

>AT58175 NZ_CP013236:c1336010-1335594 [Collimonas pratensis]
ATGAAATGCCCAACTTGCGGCGCAGCCGAACTGGCGCGCGACACACGCCTCATGCCGTACACATATAAAGGTGAATCCAC
CACGATTCCGGCAGTGAGCGGCGAATACTGCCCGGCCTGCGGCGAAGCAATTCTAGATGCGGCAGAATCGCGCCGCACCA
TGAAATTGATGAATGAATTCAACAAGCATGTGAATGCAGCGAGCGTCGATCCTGCTTTCATCACCAATGTCCGCAAAAAA
CTCGCGCTCGACCAGCGCGAGGCCGCCGAGATTTTTGGCGGCGGCGTGAATGCCTTCTCGCGCTATGAAAACGGCAAAAG
CAAACCTTCCGTGGCGCTGGTGAAATTGCTGCAGCTGCTGGACCGGCATCCCGACTTGCTGGCGGAAATAAGGACCGTTC
ACGCGGCGCCGGCATGA

Structures

Antitoxin

• AlphaFold DB: A0A127QV01