Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1321069..1321673 Replicon chromosome
Accession NZ_CP013236
Organism Collimonas pratensis strain Ter291

Toxin (Protein)


Gene name higB Uniprot ID A0A127QTU3
Locus tag CPter291_RS05940 Protein ID WP_062120441.1
Coordinates 1321069..1321380 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A127Q1V6
Locus tag CPter291_RS05945 Protein ID WP_061938158.1
Coordinates 1321383..1321673 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPter291_RS05915 1316233..1317312 - 1080 WP_062112760.1 bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada -
CPter291_RS05920 1317392..1318060 - 669 WP_061938153.1 DNA-3-methyladenine glycosylase -
CPter291_RS05925 1318060..1318713 - 654 WP_062112762.1 DNA oxidative demethylase AlkB -
CPter291_RS05930 1318723..1319463 - 741 WP_062112765.1 2OG-Fe(II) oxygenase -
CPter291_RS05935 1319700..1320905 + 1206 WP_061938157.1 MFS transporter -
CPter291_RS05940 1321069..1321380 + 312 WP_062120441.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CPter291_RS05945 1321383..1321673 + 291 WP_061938158.1 helix-turn-helix domain-containing protein Antitoxin
CPter291_RS05950 1322229..1323296 + 1068 WP_061945887.1 3-deoxy-7-phosphoheptulonate synthase AroG -
CPter291_RS05955 1323363..1324004 - 642 WP_062112768.1 TIGR02281 family clan AA aspartic protease -
CPter291_RS05960 1324278..1324763 - 486 WP_061938160.1 YajQ family cyclic di-GMP-binding protein -
CPter291_RS05970 1324956..1325987 + 1032 WP_062112772.1 UDP-N-acetylmuramate dehydrogenase -
CPter291_RS05975 1326152..1326466 - 315 WP_062112775.1 pyrimidine/purine nucleoside phosphorylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-75)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11789.67 Da        Isoelectric Point: 7.9746

>T58174 WP_062120441.1 NZ_CP013236:1321069-1321380 [Collimonas pratensis]
MEFIETPTFTRMITALLADDEYLGLQTVLVQDPSCGDVIKNGGGIRKMRYAAQGRGKSGGIRVIYYWIKDEHQIYMLVAY
PKSRKDTLSDREVAILREFVKEL

Download         Length: 312 bp

>T58174 NZ_CP013236:1321069-1321380 [Collimonas pratensis]
ATGGAATTCATTGAAACGCCTACTTTTACCCGCATGATCACAGCCTTGCTCGCTGATGACGAGTATCTAGGATTGCAAAC
TGTGCTGGTGCAGGACCCGTCTTGCGGGGATGTCATTAAAAATGGCGGTGGTATCCGTAAAATGCGTTATGCAGCGCAAG
GACGTGGCAAGAGCGGAGGAATCAGGGTGATCTATTATTGGATCAAGGACGAGCATCAGATTTATATGCTGGTGGCCTAT
CCAAAGTCTAGGAAGGACACGCTATCCGATAGGGAAGTCGCTATCTTGCGGGAGTTTGTGAAGGAGTTGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10669.41 Da        Isoelectric Point: 10.5599

>AT58174 WP_061938158.1 NZ_CP013236:1321383-1321673 [Collimonas pratensis]
MENALFEDLLQSLKEAKAISKGKLEPSRRFEMLSTDVKAVREQIGLSQSEFAKLMRVSIKTLQNWEQHRRSPTGPAAALL
KIVAAAPEVALRSLHG

Download         Length: 291 bp

>AT58174 NZ_CP013236:1321383-1321673 [Collimonas pratensis]
ATGGAAAATGCACTTTTTGAAGATCTCCTGCAGAGCCTGAAAGAGGCAAAGGCGATATCCAAGGGCAAGCTTGAACCATC
GCGCCGATTCGAGATGTTGTCTACGGACGTGAAAGCCGTCCGTGAGCAAATTGGTTTGTCTCAGAGTGAGTTTGCCAAGC
TGATGCGAGTGAGCATCAAGACTTTGCAGAACTGGGAGCAGCATCGCCGGAGCCCGACTGGCCCGGCCGCAGCGTTGCTC
AAAATTGTGGCGGCGGCGCCGGAGGTTGCGCTTCGGTCCTTGCATGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A127QTU3

Antitoxin

Source ID Structure
AlphaFold DB A0A127Q1V6

References