Detailed information of TA system TA058164

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 1282285..1282889
• Replicon: chromosome
• Accession: NZ_CP013234
• Organism: Collimonas pratensis strain Ter91

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: CPter91_RS05800
• Protein ID: WP_061945885.1
• Coordinates: 1282285..1282596 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A127Q1V6
• Locus tag: CPter91_RS05805
• Protein ID: WP_061938158.1
• Coordinates: 1282599..1282889 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CPter91_RS05775	1277449..1278528	-	1080	WP_061938150.1	bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada	-
CPter91_RS05780	1278608..1279276	-	669	WP_061938153.1	DNA-3-methyladenine glycosylase	-
CPter91_RS05785	1279276..1279929	-	654	WP_061938155.1	DNA oxidative demethylase AlkB	-
CPter91_RS05790	1279939..1280679	-	741	WP_061938156.1	2OG-Fe(II) oxygenase	-
CPter91_RS05795	1280916..1282121	+	1206	WP_061938157.1	MFS transporter	-
CPter91_RS05800	1282285..1282596	+	312	WP_061945885.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CPter91_RS05805	1282599..1282889	+	291	WP_061938158.1	helix-turn-helix domain-containing protein	Antitoxin
CPter91_RS05810	1283444..1284511	+	1068	WP_061945887.1	3-deoxy-7-phosphoheptulonate synthase AroG	-
CPter91_RS05815	1284578..1285219	-	642	WP_061938159.1	TIGR02281 family clan AA aspartic protease	-
CPter91_RS05820	1285333..1285818	-	486	WP_061938160.1	YajQ family cyclic di-GMP-binding protein	-
CPter91_RS05830	1286011..1287042	+	1032	WP_061938162.1	UDP-N-acetylmuramate dehydrogenase	-
CPter91_RS05835	1287207..1287521	-	315	WP_061938165.1	pyrimidine/purine nucleoside phosphorylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (41-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-75)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11690.53 Da
• Isoelectric Point: 6.9484

>T58164 WP_061945885.1 NZ_CP013234:1282285-1282596 [Collimonas pratensis]
MEFIETPTFTCMITALLADDEYLGLQTVLVQDPSCGDVIKNGGGIRKMRYAAQGRGKSGGIRVIYYWIKDEHQIYTLVAY
PKARKDTLSDREVAILREFVKEL

Nucleotide

• Length: 312 bp

>T58164 NZ_CP013234:1282285-1282596 [Collimonas pratensis]
ATGGAATTCATTGAAACGCCTACTTTTACCTGCATGATCACAGCCTTGCTCGCTGATGACGAGTATCTAGGATTGCAAAC
TGTGCTGGTGCAGGACCCGTCTTGCGGGGATGTCATTAAAAATGGCGGTGGTATCCGTAAAATGCGCTATGCAGCGCAAG
GACGTGGCAAGAGCGGAGGAATCAGGGTGATCTATTATTGGATCAAGGACGAGCATCAGATTTATACGCTGGTGGCCTAT
CCAAAGGCTAGGAAGGACACGCTATCCGATAGGGAGGTCGCTATCTTGCGGGAGTTTGTGAAGGAGTTGTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10669.41 Da
• Isoelectric Point: 10.5599

>AT58164 WP_061938158.1 NZ_CP013234:1282599-1282889 [Collimonas pratensis]
MENALFEDLLQSLKEAKAISKGKLEPSRRFEMLSTDVKAVREQIGLSQSEFAKLMRVSIKTLQNWEQHRRSPTGPAAALL
KIVAAAPEVALRSLHG

Nucleotide

• Length: 291 bp

>AT58164 NZ_CP013234:1282599-1282889 [Collimonas pratensis]
ATGGAAAATGCACTTTTTGAAGATCTCCTGCAGAGCCTGAAAGAGGCAAAGGCGATATCCAAGGGCAAGCTTGAACCATC
GCGCCGATTCGAGATGTTGTCTACGGACGTGAAAGCCGTCCGTGAGCAAATTGGTTTGTCTCAGAGTGAGTTTGCCAAGC
TGATGCGAGTGAGCATCAAGACTTTGCAGAACTGGGAGCAGCATCGTCGGAGCCCGACTGGCCCGGCCGCAGCGTTGCTC
AAAATTGTGGCGGCGGCGCCGGAGGTTGCGCTTCGGTCCTTGCATGGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A127Q1V6