Detailed information of TA system TA058159

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 4760087..4760720
• Replicon: chromosome
• Accession: NZ_CP013232
• Organism: Collimonas fungivorans strain Ter6

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: CFter6_RS20890
• Protein ID: WP_205631413.1
• Coordinates: 4760388..4760720 (-)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A127R352
• Locus tag: CFter6_RS20885
• Protein ID: WP_041742396.1
• Coordinates: 4760087..4760371 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CFter6_RS20875	4755399..4757621	-	2223	WP_061541550.1	type I secretion system permease/ATPase	-
CFter6_RS20880	4758167..4759693	-	1527	WP_061541551.1	hypothetical protein	-
CFter6_RS20885	4760087..4760371	-	285	WP_041742396.1	helix-turn-helix domain-containing protein	Antitoxin
CFter6_RS20890	4760388..4760720	-	333	WP_205631413.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CFter6_RS20895	4761015..4761377	-	363	WP_061541552.1	hypothetical protein	-
CFter6_RS20900	4761794..4762801	-	1008	WP_061542507.1	DUF475 domain-containing protein	-
CFter6_RS20905	4763190..4764137	-	948	WP_061541553.1	OmpA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (16-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (32-90)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 12728.11 Da
• Isoelectric Point: 10.4134

>T58159 WP_205631413.1 NZ_CP013232:c4760720-4760388 [Collimonas fungivorans]
MIEYQVSYYSQQIQADIMSLPATLQARYLSLTARMKIYGPHLGEPHTKVLGNGLLELRLKGAEGIARVFYCTMVGKQIVM
LHSFVKKTQKIPFKEKRIAEIRMREVKNER

Nucleotide

• Length: 333 bp

>T58159 NZ_CP013232:c4760720-4760388 [Collimonas fungivorans]
ATGATCGAATATCAGGTTAGTTACTATAGCCAACAGATCCAGGCAGACATTATGTCCTTGCCGGCAACGCTGCAGGCACG
CTATCTCAGCTTGACCGCCAGAATGAAGATTTACGGCCCTCATTTGGGGGAGCCTCATACCAAGGTGCTTGGCAATGGCT
TGCTTGAGTTACGCTTGAAGGGCGCGGAAGGCATTGCCCGTGTTTTTTATTGCACGATGGTCGGGAAGCAGATTGTCATG
CTGCACAGTTTCGTCAAGAAGACACAAAAAATTCCTTTTAAGGAAAAACGGATTGCAGAAATTCGCATGAGGGAAGTTAA
AAATGAGCGCTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10397.00 Da
• Isoelectric Point: 9.7320

>AT58159 WP_041742396.1 NZ_CP013232:c4760371-4760087 [Collimonas fungivorans]
MTHEEMQARMLQNPVVQAEYERLNREEFAILDEILAARKAAGLTQAQIAERMGTKAPAVARLESSLASGKHSPSINTLRK
YAAALGKRLEVHLV

Nucleotide

• Length: 285 bp

>AT58159 NZ_CP013232:c4760371-4760087 [Collimonas fungivorans]
ATGACGCATGAAGAAATGCAGGCTCGGATGCTGCAGAATCCCGTTGTCCAGGCTGAATACGAACGCTTGAATCGCGAGGA
GTTTGCCATTCTTGACGAAATTTTAGCGGCACGCAAAGCGGCTGGACTCACCCAGGCACAGATTGCCGAACGTATGGGAA
CCAAGGCGCCAGCCGTGGCGCGCCTGGAAAGTTCATTAGCTTCGGGTAAGCACTCTCCTAGCATCAATACATTACGCAAA
TATGCGGCAGCGCTTGGAAAACGCCTCGAAGTGCATCTGGTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A127R352