Detailed information of TA system TA058158

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4383057..4383656
• Replicon: chromosome
• Accession: NZ_CP013232
• Organism: Collimonas fungivorans strain Ter6

Toxin (Protein)

• Gene name: graT
• Uniprot ID: -
• Locus tag: CFter6_RS25190
• Protein ID: WP_082814876.1
• Coordinates: 4383057..4383335 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A127PG61
• Locus tag: CFter6_RS19150
• Protein ID: WP_061541268.1
• Coordinates: 4383345..4383656 (+)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CFter6_RS19125	4378572..4379468	+	897	WP_061541266.1	DMT family transporter	-
CFter6_RS19130	4379503..4380117	+	615	WP_014007328.1	TIGR00645 family protein	-
CFter6_RS19135	4380209..4381747	+	1539	WP_061542474.1	fumarate hydratase	-
CFter6_RS19140	4381791..4382636	+	846	WP_167351465.1	glutamate racemase	-
CFter6_RS25190	4383057..4383335	+	279	WP_082814876.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CFter6_RS19150	4383345..4383656	+	312	WP_061541268.1	HigA family addiction module antidote protein	Antitoxin
CFter6_RS19155	4383701..4384339	-	639	WP_061541269.1	LysE family transporter	-
CFter6_RS19160	4384458..4385619	-	1162	Protein_3877	cyclopropane fatty acyl phospholipid synthase	-
CFter6_RS19165	4385669..4386316	-	648	WP_061541270.1	LysE family translocator	-
CFter6_RS19170	4386361..4387209	-	849	WP_061541271.1	aldo/keto reductase	-
CFter6_RS19175	4387318..4388172	+	855	WP_061541272.1	isocitrate lyase/phosphoenolpyruvate mutase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (1-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (5-99)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10299.74 Da
• Isoelectric Point: 8.5275

>T58158 WP_082814876.1 NZ_CP013232:4383057-4383335 [Collimonas fungivorans]
MILSFRCASTQALFEGLRVAKFANVSNVAERKLQQLDSAATLGFLRSPPGNRLEALAGNRAGQYSIRVNDQWRICFIWTE
QGVANVEIVDYH

Nucleotide

• Length: 279 bp

>T58158 NZ_CP013232:4383057-4383335 [Collimonas fungivorans]
ATGATACTCAGCTTTCGCTGTGCCAGCACCCAAGCCCTGTTTGAAGGCCTCCGCGTTGCGAAATTTGCAAACGTCTCCAA
TGTTGCAGAACGAAAACTTCAACAGTTGGATAGTGCGGCGACACTCGGCTTTCTCCGTTCACCGCCCGGCAATCGTTTGG
AAGCGTTGGCTGGCAATCGCGCCGGCCAATACAGTATTCGTGTAAATGATCAGTGGCGCATCTGCTTCATCTGGACTGAG
CAGGGAGTGGCAAATGTTGAGATCGTTGATTACCACTAG

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11634.47 Da
• Isoelectric Point: 8.6245

>AT58158 WP_061541268.1 NZ_CP013232:4383345-4383656 [Collimonas fungivorans]
MSKIRNGMRPIHPGEILREDYLKQIPMSANALAIALHVPATRISEIVHERRGITTDTALRLARFFGNDAQSWLNLQQAYD
LKMAETEILEKIAREVQPLAQAA

Nucleotide

• Length: 312 bp

>AT58158 NZ_CP013232:4383345-4383656 [Collimonas fungivorans]
ATGAGCAAAATCAGAAATGGCATGCGCCCGATCCACCCGGGAGAAATTTTGCGTGAAGACTACCTGAAGCAGATTCCGAT
GAGCGCCAACGCTCTCGCCATAGCGCTTCATGTTCCTGCCACTCGCATCAGTGAAATCGTGCACGAACGACGCGGCATAA
CTACCGACACTGCCTTACGTCTCGCTCGCTTTTTTGGCAATGACGCGCAATCCTGGCTGAACCTGCAGCAAGCCTACGAT
CTGAAGATGGCGGAAACGGAAATCCTGGAGAAAATTGCAAGAGAGGTACAGCCTCTGGCGCAAGCTGCCTGA

Structures

Antitoxin

• AlphaFold DB: A0A127PG61