Detailed information of TA system TA058156

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 4231739..4232343
• Replicon: chromosome
• Accession: NZ_CP013232
• Organism: Collimonas fungivorans strain Ter6

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: CFter6_RS18425
• Protein ID: WP_061542459.1
• Coordinates: 4232032..4232343 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A127PFV8
• Locus tag: CFter6_RS18420
• Protein ID: WP_061541154.1
• Coordinates: 4231739..4232029 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CFter6_RS18395	4227402..4227713	+	312	WP_061541150.1	pyrimidine/purine nucleoside phosphorylase	-
CFter6_RS18400	4227867..4228907	-	1041	WP_061541151.1	UDP-N-acetylmuramate dehydrogenase	-
CFter6_RS18405	4229080..4229565	+	486	WP_014007212.1	YajQ family cyclic di-GMP-binding protein	-
CFter6_RS18410	4229648..4230304	+	657	WP_082814857.1	TIGR02281 family clan AA aspartic protease	-
CFter6_RS18415	4230359..4231426	-	1068	WP_061541153.1	3-deoxy-7-phosphoheptulonate synthase AroG	-
CFter6_RS18420	4231739..4232029	-	291	WP_061541154.1	helix-turn-helix domain-containing protein	Antitoxin
CFter6_RS18425	4232032..4232343	-	312	WP_061542459.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CFter6_RS18430	4232588..4233792	-	1205	Protein_3727	MFS transporter	-
CFter6_RS18435	4233972..4234982	-	1011	WP_061539234.1	IS110 family transposase	-
CFter6_RS18440	4235316..4235879	+	564	WP_061541155.1	methylated-DNA--[protein]-cysteine S-methyltransferase	-
CFter6_RS18445	4235876..4236619	+	744	WP_061541156.1	2OG-Fe(II) oxygenase	-
CFter6_RS18450	4236630..4237292	+	663	WP_061541157.1	DNA oxidative demethylase AlkB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (42-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-82)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11990.00 Da
• Isoelectric Point: 9.8148

>T58156 WP_061542459.1 NZ_CP013232:c4232343-4232032 [Collimonas fungivorans]
MEFIETPTFTRMITALLAEEEYRKLQSVLMEDPSRGDVIKDGGGIRKMRYAARGRGKSGGIRVIYYWIKDNHQIYMLVAY
PKSKKDTLTDKEIAILREFVKEL

Nucleotide

• Length: 312 bp

>T58156 NZ_CP013232:c4232343-4232032 [Collimonas fungivorans]
ATGGAATTCATCGAGACTCCTACTTTTACTCGTATGATCACGGCGTTGCTTGCAGAGGAAGAATATCGGAAACTGCAATC
GGTACTGATGGAGGATCCGTCACGGGGCGATGTCATCAAAGATGGCGGCGGCATTCGCAAAATGCGGTACGCAGCGCGAG
GTCGTGGCAAAAGCGGAGGAATCAGAGTGATCTATTATTGGATAAAGGATAACCATCAAATTTACATGTTAGTGGCCTAT
CCGAAATCAAAAAAAGATACGCTAACCGATAAGGAAATTGCTATTTTGAGAGAGTTTGTGAAGGAGTTGTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10614.25 Da
• Isoelectric Point: 10.5624

>AT58156 WP_061541154.1 NZ_CP013232:c4232029-4231739 [Collimonas fungivorans]
MENALFDDLLQSLKEAKAISQGKAEASRRFQMPPTDVKAVREQIGLSQSEFAKLMRVSIKTLQNWEQHRRSPTGPAAALL
KIVSTAPDVALKSLHS

Nucleotide

• Length: 291 bp

>AT58156 NZ_CP013232:c4232029-4231739 [Collimonas fungivorans]
ATGGAAAATGCACTTTTTGATGATCTGCTGCAGAGCCTGAAAGAAGCAAAGGCTATTTCCCAAGGGAAAGCTGAGGCATC
GCGCCGATTTCAGATGCCGCCTACTGACGTAAAAGCCGTTCGCGAGCAAATTGGCTTATCTCAGAGCGAATTTGCAAAAC
TGATGCGTGTCAGTATCAAGACCTTGCAAAACTGGGAGCAGCACCGACGCAGTCCGACTGGTCCGGCTGCCGCTTTGCTC
AAAATTGTATCAACGGCACCGGATGTCGCGCTTAAGTCATTGCATAGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A127PFV8