Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1617839..1618362 Replicon chromosome
Accession NZ_CP013231
Organism Staphylococcus aureus strain UTSW MRSA 55

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag AS858_RS09290 Protein ID WP_000074048.1
Coordinates 1617839..1618105 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag AS858_RS09295 Protein ID WP_000587616.1
Coordinates 1618105..1618362 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AS858_RS09270 1613146..1614333 - 1188 WP_000026194.1 MFS transporter -
AS858_RS09275 1614729..1615505 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
AS858_RS09280 1615498..1616160 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
AS858_RS09285 1616408..1617484 - 1077 WP_001076671.1 M42 family metallopeptidase -
AS858_RS09290 1617839..1618105 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
AS858_RS09295 1618105..1618362 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AS858_RS09305 1618721..1619176 + 456 WP_000732082.1 DUF1307 domain-containing protein -
AS858_RS09310 1619344..1620921 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
AS858_RS09315 1621116..1621865 + 750 WP_000072444.1 hypothetical protein -
AS858_RS09320 1622089..1623282 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T58149 WP_000074048.1 NZ_CP013231:c1618105-1617839 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T58149 NZ_CP013231:c1618105-1617839 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT58149 WP_000587616.1 NZ_CP013231:c1618362-1618105 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT58149 NZ_CP013231:c1618362-1618105 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References