Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 1586339..1586523 Replicon chromosome
Accession NZ_CP013231
Organism Staphylococcus aureus strain UTSW MRSA 55

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag AS858_RS09135 Protein ID WP_000482650.1
Coordinates 1586416..1586523 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 1586339..1586399 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AS858_RS09110 1581869..1582036 - 168 WP_001790576.1 hypothetical protein -
AS858_RS09120 1582267..1584000 - 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
AS858_RS09125 1584025..1585788 - 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
- 1586339..1586399 + 61 - - Antitoxin
AS858_RS09135 1586416..1586523 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
AS858_RS09140 1586657..1587043 - 387 WP_000779358.1 flippase GtxA -
AS858_RS09145 1587311..1588453 + 1143 WP_001176863.1 glycerate kinase -
AS858_RS09150 1588513..1589172 + 660 WP_000831298.1 membrane protein -
AS858_RS09155 1589354..1590565 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
AS858_RS09160 1590688..1591161 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T58147 WP_000482650.1 NZ_CP013231:c1586523-1586416 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T58147 NZ_CP013231:c1586523-1586416 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT58147 NZ_CP013231:1586339-1586399 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References