Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1560991..1561508 Replicon chromosome
Accession NZ_CP013231
Organism Staphylococcus aureus strain UTSW MRSA 55

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag AS858_RS08980 Protein ID WP_000113262.1
Coordinates 1560991..1561257 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A5A8VWS3
Locus tag AS858_RS08985 Protein ID WP_000584502.1
Coordinates 1561257..1561508 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AS858_RS08955 1556417..1556953 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
AS858_RS08960 1557186..1558010 - 825 WP_000572040.1 formate/nitrite transporter family protein -
AS858_RS08965 1558227..1558409 - 183 WP_000230294.1 hypothetical protein -
AS858_RS08970 1558493..1558960 - 468 WP_000153344.1 SRPBCC domain-containing protein -
AS858_RS08975 1559146..1560696 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
AS858_RS16845 1560885..1560956 - 72 Protein_1545 hypothetical protein -
AS858_RS08980 1560991..1561257 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
AS858_RS08985 1561257..1561508 - 252 WP_000584502.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AS858_RS08990 1561673..1561774 - 102 WP_001791744.1 hypothetical protein -
AS858_RS08995 1561781..1562380 - 600 WP_000162813.1 DsbA family protein -
AS858_RS09000 1562399..1562758 - 360 WP_000819847.1 DUF4467 domain-containing protein -
AS858_RS09005 1563013..1564263 + 1251 WP_061491687.1 FemA/FemB family glycyltransferase FmhA -
AS858_RS09010 1564360..1565091 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
AS858_RS09015 1565088..1565807 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T58146 WP_000113262.1 NZ_CP013231:c1561257-1560991 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T58146 NZ_CP013231:c1561257-1560991 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9417.65 Da        Isoelectric Point: 4.4702

>AT58146 WP_000584502.1 NZ_CP013231:c1561508-1561257 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSVMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT58146 NZ_CP013231:c1561508-1561257 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGTTATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB A0A5A8VWS3

References