Detailed information of TA system TA058138

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 1120060..1120359
• Replicon: chromosome
• Accession: NZ_CP013231
• Organism: Staphylococcus aureus strain UTSW MRSA 55

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: AS858_RS16050
• Protein ID: WP_011447039.1
• Coordinates: 1120183..1120359 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	1120060..1120115 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AS858_RS06520	1115391..1115651	+	261	WP_001791826.1	hypothetical protein	-
AS858_RS06525	1115704..1116054	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
AS858_RS06530	1116739..1117188	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
AS858_RS16815	1117283..1117618	-	336	Protein_1080	SH3 domain-containing protein	-
AS858_RS06540	1118268..1118759	-	492	WP_000919350.1	staphylokinase	-
AS858_RS06545	1118950..1119705	-	756	WP_000861038.1	CHAP domain-containing protein	-
AS858_RS06550	1119717..1119971	-	255	WP_000611512.1	phage holin	-
AS858_RS06555	1120023..1120130	+	108	WP_001791821.1	hypothetical protein	-
-	1120052..1120191	+	140	NuclAT_0	-	-
-	1120052..1120191	+	140	NuclAT_0	-	-
-	1120052..1120191	+	140	NuclAT_0	-	-
-	1120052..1120191	+	140	NuclAT_0	-	-
-	1120060..1120115	+	56	-	-	Antitoxin
AS858_RS16050	1120183..1120359	-	177	WP_011447039.1	putative holin-like toxin	Toxin
AS858_RS06560	1120509..1120805	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
AS858_RS06565	1120863..1121150	-	288	WP_001040261.1	hypothetical protein	-
AS858_RS06570	1121197..1121349	-	153	WP_001153681.1	hypothetical protein	-
AS858_RS06575	1121339..1125124	-	3786	WP_000582165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	1115704..1174671	58967

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T58138 WP_011447039.1 NZ_CP013231:c1120359-1120183 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T58138 NZ_CP013231:c1120359-1120183 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT58138 NZ_CP013231:1120060-1120115 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin